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T Cell Transcription Factor 1

Known as: TCF7, TCF-7, TCF-1 Transcription Factor 
A TCF transcription factor that was originally identified as a DNA-binding protein that interacts with the enhancers of T-CELL RECEPTOR ALPHA GENES… 
National Institutes of Health

Related topics

Related topics

23 relations
Cell NucleusDNA-Binding ProteinsGenes, RegulatorImmune response

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Regulation of the TMEPAI promoter by TCF7L2: the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene.
We previously found that TCF7L2 could activate the TMEPAI gene efficiently, whereas LEF1 could not nearly augment its… 
2015
2015
ILC development: TCF-1 reporting in
The transcriptional regulator TCF-1 marks rare progenitor cells in adult bone marrow that have lost the potential to develop into… 
2015
2015
Augmenting NF-κB in poor-risk CLL: A general paradigm for other cancers?
![Figure][1] Insight from David Tuveson (left) and Kanti Rai (right) Chronic lymphocytic leukemia (CLL) is a chronic… 
2013
2013
Role of ATF7‐TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease
Osteoclast (OCL) precursors from many Paget's disease (PD) patients express measles virus nucleocapsid protein (MVNP) and are… 
2012
2012
Notch Signalling Inhibits CD4 Expression during Initiation and Differentiation of Human T Cell Lineage
The Delta/Notch signal transduction pathway is central to T cell differentiation from haemopoietic stem cells (HSCs). Although T… 
2010
2010
The balance of TCF7L2 variants with differential activities in Wnt-signaling is regulated by lithium in a GSK3beta-independent manner.
2006
2006
Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis
Previous linkage studies have suggested that chromosome 12 may harbor susceptibility genes for late-onset Alzheimer disease (LOAD… 
2002
2002
Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency
Apc (adenomatous polyposis coli) encodes a tumour suppressor gene that is mutated in the majority of colorectal cancers. Recent… 
1998
1998
Expression of Tcf-1 mRNA and surface TCR-CD3 complexes are reduced during apoptosis of T cells.
When a T cell hybridoma, 70.7, was treated with a Ca2+ ionophore (A23187), apoptotic cell death was induced. Interestingly, we… 
1996
1996
An enhancer LEF-1/TCF-1 site is essential for insertion site-independent transgene expression in thymus.
Transcriptional activation of eukaryotic genes involves assembly of specific multiprotein complexes on the promoters and… 
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