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T-Cell Surface Glycoprotein CD3 Zeta Chain

Known as: CD3-Zeta, T-Cell Receptor T3 Zeta Chain, CD3z 
T-cell surface glycoprotein CD3 zeta chain (164 aa, ~18 kDa) is encoded by the human CD247 gene. This protein is involved in T-cell intracellular… 
National Institutes of Health

Related topics

Related topics

12 relations
CD247 geneCD247 wt AlleleCD3 AntigensCTL-mediated Immune Response Pathway

Papers overview

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2004
2004
Alterations in T-cell signal transduction molecules associated with recurrent spontaneous pregnancy loss.
2004
2004
Epitope‐specific crosslinking of CD45 down‐regulates membrane‐associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells
CD45 engagement by monoclonal antibodies on human activated T cells triggers tumour necrosis factor‐α (TNF‐α) gene transcription… 
2002
2002
Convergence of experimental, computational and evolutionary approaches predicts the presence of a tetrameric form for CD3-zeta.
Experimental results using multiple site-specific infrared dichroism have shown that, when reconstituted into lipid bilayers, the… 
2002
2002
Modulation of T‐Cell CD3‐Zeta Chain Expression in Early Pregnancy *
PROBLEM: To assess the modulation of T‐cell CD3‐zeta chain expression by a factor in the sera of women, prior to egg retrieval… 
2002
2002
Multiple site-specific infrared dichroism of CD3-zeta, a transmembrane helix bundle.
The structure of the transmembrane domain of CD3-zeta a component of the T-cell receptor involved in signal transduction, has… 
2002
2002
T‐cell‐rich B‐cell lymphoma – diagnostic and therapeutic aspects
Background. Morphologically, T‐cell‐rich B‐cell lymphoma (TCRB‐NHL) may be indistinguishable from Hodgkin's disease (HD… 
Highly Cited
1997
Highly Cited
1997
Tyrosine Phosphorylation of the CD3-ε Subunit of the T Cell Antigen Receptor Mediates Enhanced Association with Phosphatidylinositol 3-Kinase in Jurkat T Cells*
T cell receptor signaling results both in T cell proliferation and apoptosis. A key enzyme at the intersection of these… 
1995
1995
Do Structural Changes of T Cell Receptor Complex Occur in Tumor‐bearing State?
T cells in tumor‐bearing mice and cancer patients were recently shown to be devoid of CD3‐ζ chain, a signal‐transducing invariant… 
1994
1994
Molecular associations involving CD 16, CD45 and ζ, and γ chains on human natural killer cells
ζ (CD3‐ζ) and γ (FcεRIγ) chains associate with CD 16. the low affinity receptor for IgG (FcλRIII) on human NK cells and are… 
1990
1990
Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain.
The TCR for Ag, on the majority of human T cells, is a disulfide-linked heterodimer composed of TCR-alpha and -beta chains… 
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