T-Cell Receptor Activation
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Amino‐acid catabolizing enzymes produced by mononuclear phagocytes play a central role in regulating the immune response. The… Expand Acid sphingomyelinase (ASM), a lipid hydrolase enzyme, has the potential to modulate various cellular activation responses via… Expand Antigen recognition through the interaction between the T cell receptor (TCR) and peptide presented by major histocompatibility… Expand BackgroundTCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic… Expand Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell… Expand Gene transfer into T lymphocytes is currently being tested for the treatment of lymphohematologic disorders. We previously showed… Expand In this report, we review a novel method for probing the membrane organization of T cells using dimeric major histocompatibility… Expand Cloned T regulatory type 1 (Tr1) cells produce IL‐10, TGF‐β, IFN‐γ, and very low or non‐detectable levels of IL‐2 and IL‐4… Expand Human lymphocytes expressing the gammadelta TCR represent a minor T cell subpopulation found in blood. The majority of these… Expand Strong stimulation of the T-cell receptor (TCR) on cycling peripheral T cells causes their apoptosis by a process called TCR… Expand