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T-Cell Receptor Activation

Known as: T-Cell Receptor Interaction, TCR Activation, TCR Interaction 
Any process in which a specific pair of interactions is observed between a T cell and an antigen-presenting cell, where the interactions include… Expand
National Institutes of Health

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Related topics

16 relations
Antigen PresentationB7 Transfected Melanoma Cell VaccineCD3D geneCD3D protein, human
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
IL4-induced gene 1 is secreted at the immune synapse and modulates TCR activation independently of its enzymatic activity.
Amino-acid catabolizing enzymes produced by mononuclear phagocytes play a central role in regulating the immune response. The… Expand
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2015
2015
Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses
Acid sphingomyelinase (ASM), a lipid hydrolase enzyme, has the potential to modulate various cellular activation responses via… Expand
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Highly Cited
2013
Highly Cited
2013
CD73 expression on extracellular vesicles derived from CD4+ CD25+ Foxp3+ T cells contributes to their regulatory function.
CD4(+)CD25(+)Foxp3(+) Treg cells maintain immunological tolerance. In this study, the possibility that Treg cells control immune… Expand
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2008
2008
Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation
BackgroundTCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic… Expand
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2004
2004
Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.
Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell… Expand
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Highly Cited
2003
Highly Cited
2003
Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence.
Gene transfer into T lymphocytes is currently being tested for the treatment of lymphohematologic disorders. We previously showed… Expand
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Review
2002
Review
2002
Probing T cell membrane organization using dimeric MHC-Ig complexes.
In this report, we review a novel method for probing the membrane organization of T cells using dimeric major histocompatibility… Expand
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Highly Cited
2002
Highly Cited
2002
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines.
Cloned T regulatory type 1 (Tr1) cells produce IL-10, TGF-beta, IFN-gamma, and very low or non-detectable levels of IL-2 and IL-4… Expand
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2001
2001
Production of TNF-alpha by human V gamma 9V delta 2 T cells via engagement of Fc gamma RIIIA, the low affinity type 3 receptor for the Fc portion of IgG, expressed upon TCR activation by nonpeptidic…
Human lymphocytes expressing the gammadelta TCR represent a minor T cell subpopulation found in blood. The majority of these… Expand
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Highly Cited
2000
Highly Cited
2000
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
Strong stimulation of the T-cell receptor (TCR) on cycling peripheral T cells causes their apoptosis by a process called TCR… Expand
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