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T-Cell Receptor Activation

Known as: T-Cell Receptor Interaction, TCR Activation, TCR Interaction 
Any process in which a specific pair of interactions is observed between a T cell and an antigen-presenting cell, where the interactions include… Expand
National Institutes of Health

Related topics

Related topics

16 relations
Antigen PresentationB7 Transfected Melanoma Cell VaccineCD3D geneCD3D protein, human
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
IL4‐induced gene 1 is secreted at the immune synapse and modulates TCR activation independently of its enzymatic activity
Amino‐acid catabolizing enzymes produced by mononuclear phagocytes play a central role in regulating the immune response. The… Expand
2015
2015
Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses
Acid sphingomyelinase (ASM), a lipid hydrolase enzyme, has the potential to modulate various cellular activation responses via… Expand
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Highly Cited
2010
Highly Cited
2010
T cell receptor triggering by force.
Antigen recognition through the interaction between the T cell receptor (TCR) and peptide presented by major histocompatibility… Expand
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2008
2008
Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation
BackgroundTCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic… Expand
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2004
2004
Cognate MHC–TCR interaction leads to apoptosis of antigen‐presenting cells
Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell… Expand
Highly Cited
2003
Highly Cited
2003
Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence.
Gene transfer into T lymphocytes is currently being tested for the treatment of lymphohematologic disorders. We previously showed… Expand
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Review
2002
Review
2002
Probing T cell membrane organization using dimeric MHC-Ig complexes.
In this report, we review a novel method for probing the membrane organization of T cells using dimeric major histocompatibility… Expand
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Highly Cited
2002
Highly Cited
2002
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines
Cloned T regulatory type 1 (Tr1) cells produce IL‐10, TGF‐β, IFN‐γ, and very low or non‐detectable levels of IL‐2 and IL‐4… Expand
2001
2001
Production of TNF-alpha by human V gamma 9V delta 2 T cells via engagement of Fc gamma RIIIA, the low affinity type 3 receptor for the Fc portion of IgG, expressed upon TCR activation by nonpeptidic…
Human lymphocytes expressing the gammadelta TCR represent a minor T cell subpopulation found in blood. The majority of these… Expand
Highly Cited
2000
Highly Cited
2000
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
Strong stimulation of the T-cell receptor (TCR) on cycling peripheral T cells causes their apoptosis by a process called TCR… Expand
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