Skip to search formSkip to main contentSkip to account menu

T-Cell Receptor Activation

Known as: T-Cell Receptor Interaction, TCR Activation, TCR Interaction 
Any process in which a specific pair of interactions is observed between a T cell and an antigen-presenting cell, where the interactions include… 
National Institutes of Health

Related topics

Related topics

16 relations
Antigen PresentationB7 Transfected Melanoma Cell VaccineCD3D geneCD3D protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
IL4‐induced gene 1 is secreted at the immune synapse and modulates TCR activation independently of its enzymatic activity
Amino‐acid catabolizing enzymes produced by mononuclear phagocytes play a central role in regulating the immune response. The… 
2015
2015
Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses
Acid sphingomyelinase (ASM), a lipid hydrolase enzyme, has the potential to modulate various cellular activation responses via… 
Highly Cited
2013
Highly Cited
2013
CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+ T cells contributes to their regulatory function
CD4+CD25+Foxp3+ Treg cells maintain immunological tolerance. In this study, the possibility that Treg cells control immune… 
2008
2008
Interplay between the heterotrimeric G-protein subunits Gαq and Gαi2 sets the threshold for chemotaxis and TCR activation
BackgroundTCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic… 
2004
2004
Cognate MHC–TCR interaction leads to apoptosis of antigen‐presenting cells
Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell… 
Highly Cited
2003
Highly Cited
2003
Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence.
Gene transfer into T lymphocytes is currently being tested for the treatment of lymphohematologic disorders. We previously showed… 
Review
2002
Review
2002
Probing T cell membrane organization using dimeric MHC-Ig complexes.
Highly Cited
2002
Highly Cited
2002
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines
Cloned T regulatory type 1 (Tr1) cells produce IL‐10, TGF‐β, IFN‐γ, and very low or non‐detectable levels of IL‐2 and IL‐4… 
2001
2001
Production of TNF-alpha by human V gamma 9V delta 2 T cells via engagement of Fc gamma RIIIA, the low affinity type 3 receptor for the Fc portion of IgG, expressed upon TCR activation by nonpeptidic…
Human lymphocytes expressing the gammadelta TCR represent a minor T cell subpopulation found in blood. The majority of these… 
Highly Cited
2000
Highly Cited
2000
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
Strong stimulation of the T-cell receptor (TCR) on cycling peripheral T cells causes their apoptosis by a process called TCR… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License