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T-Cell Receptor Activation

Known as: T-Cell Receptor Interaction, TCR Activation, TCR Interaction 
Any process in which a specific pair of interactions is observed between a T cell and an antigen-presenting cell, where the interactions include… 
National Institutes of Health

Related topics

Related topics

16 relations
Antigen PresentationB7 Transfected Melanoma Cell VaccineCD3D geneCD3D protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Human β‐defensin 3 induces STAT1 phosphorylation, tyrosine phosphatase activity, and cytokine synthesis in T cells
The AMP hBD‐3 stimulates numerous immune effector functions in myeloid cells and keratinocytes, predominantly through the MAPK… 
2008
2008
TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine/paracrine granzyme B-mediated proteolytic cleavage.
The majority of resting normal human T cells, like neuronal cells, express functional receptors for glutamate (the major… 
2004
2004
Cognate MHC–TCR interaction leads to apoptosis of antigen‐presenting cells
Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell… 
2003
2003
Requirement for Q226, but not multiple charged residues, in the class I MHC CD loop/D strand for TCR‐activated CD8 accessory function
Activation of CD8+ cytotoxic T lymphocytes typically begins with recognition of class I MHC‐peptide complexes by the TCR and CD8… 
Highly Cited
2002
Highly Cited
2002
IL‐15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL‐12 / IL‐4 stimulation in vitro
Interleukin 15 (IL‐15) is a pleiotropic cytokine produced principally by monocytes and affects both innate and acquired immunity… 
2002
2002
T cell antigen receptor (TCR) transmembrane peptides colocalize with TCR, not lipid rafts, in surface membranes.
2002
2002
Autocrine IL-4 Gene Regulation at Late Phases of TCR Activation in Differentiated Th2 Cells1
IL-4 is a multifunctional cytokine whose secretion displays important immunomodulatory functions. Its expression is regulated at… 
2001
2001
Interleukin 12 and antigen independently induce substance P receptor expression in T cells in murine schistosomiasis mansoni.
Substance P (SP) regulates interferon-gamma (IFN-gamma) production through interaction with the SP receptor NK1 (SPr) on T cells… 
Highly Cited
1996
Highly Cited
1996
Quantitative analysis of the expression of the HLA-DRB genes at the transcriptional level by competitive polymerase chain reaction.
In addition to polymorphism of the peptide-binding site, the density of the MHC class II molecules expressed on the membrane of… 
Review
1993
Review
1993
Interaction of the T cell receptor with bacterial superantigens.
Bacterial toxin superantigens bind to MHC class II molecules and activate a large proportion of T cells through a direct… 
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