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Suramin

Known as: 1,3,5-Naphthalenetrisulfonic acid, 8,8'-(carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-, Suramin [Chemical/Ingredient], 8,8'-[CARBONYLBIS[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid 
A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Sirtuins are NAD(+)-dependent protein deacetylases and are emerging as molecular targets for the development of pharmaceuticals… Expand
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Review
2001
Review
2001
Angiogenesis is a fundamental process in reproduction and wound healing. Under these conditions, neovascularization is tightly… Expand
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Highly Cited
1996
Highly Cited
1996
The mitogen-activated protein kinase (MAPK) family is comprised of key regulatory proteins that control the cellular response to… Expand
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Highly Cited
1996
Highly Cited
1996
Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed. All six proteins are 36–48 percent identical and seem to… Expand
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Highly Cited
1992
Highly Cited
1992
The vascular endothelial growth factor (VEGF) family encompasses four polypeptides that result from alternative splicing of mRNA… Expand
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Highly Cited
1992
Highly Cited
1992
UNTIL now, the only well documented, fast excitatory neurotrans-mitter in the brain has been glutamate. Although there is… Expand
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Highly Cited
1989
Highly Cited
1989
We administered suramin, an anti-parasitic drug and reverse transcriptase inhibitor, to 15 patients with metastatic cancer. This… Expand
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Highly Cited
1987
Highly Cited
1987
Suramin, a polyanionic compound, has previously been shown to dissociate platelet‐derived growth factor (PDGF) from its receptor… Expand
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Highly Cited
1984
Highly Cited
1984
A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to… Expand
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Review
1978
Review
1978
  • F. Hawking
  • Advances in pharmacology and chemotherapy
  • 1978
  • Corpus ID: 6898571
Publisher Summary This chapter discusses the suramin with special reference to onchocerciasis. Suramin is a pinkish white… Expand
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