Suppressor of Cytokine Signaling 1

Known as: Tec-Interacting Protein 3, SOCS1, STAT-Induced STAT Inhibitor 1 
Suppressor of cytokine signaling 1 (211 aa, ~24 kDa) is encoded by the human SOCS1 gene. This protein is involved in the modulation of cytokine… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Macrophages become activated by their environment and develop polarized functions: classically activated (M1) macrophages… (More)
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Highly Cited
2006
Highly Cited
2006
Toll-like receptor (TLR) signals that initiate innate immune responses to pathogens must be tightly regulated to prevent… (More)
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Highly Cited
2004
Highly Cited
2004
Suppressor of cytokine signaling (SOCS) proteins constitute a class of negative regulators for Janus kinase/signal transducer and… (More)
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Highly Cited
2004
Highly Cited
2004
Insulin resistance, obesity, diabetes, dyslipidemia, and nonalcoholic fatty liver are components of the metabolic syndrome, a… (More)
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Highly Cited
2003
Highly Cited
2003
The suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the negative regulation of several cytokine… (More)
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Highly Cited
2002
Highly Cited
2002
Inflammation associates with peripheral insulin resistance, which dysregulates nutrient homeostasis and leads to diabetes… (More)
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Highly Cited
2002
Highly Cited
2002
SOCS-1 is a negative regulatory molecule of the JAK-STAT signal cascade. Here, we demonstrate that SOCS-1 is a critical… (More)
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Highly Cited
2001
Highly Cited
2001
Insulin resistance contributes to a number of metabolic disorders, including type II diabetes, hypertension, and atherosclerosis… (More)
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Highly Cited
1998
Highly Cited
1998
SOCS-1, a member of the suppressor of cytokine signaling (SOCS) family, was identified in a genetic screen for inhibitors of… (More)
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Highly Cited
1997
Highly Cited
1997
Cytokines are secreted proteins that regulate important cellular responses such as proliferation and differentiation. Key events… (More)
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