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Sulfinpyrazone

Known as: Sulphinpyrazone, 3,5-Pyrazolidinedione, 1,2-diphenyl-4-(2-(phenylsulfinyl)ethyl)-, Sulfoxyphenylpyrazolidine 
A phenylbutazone derivative with uricosuric and antithrombotic properties. Sulfinpyrazone competitively inhibits reabsorption of urate at the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Relatively few selective substrate and inhibitor probes have been identified for human UDP-glucuronosyltransferases (UGTs). This… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND The desired serum urate level (SUA) for prevention of gout attacks is widely recommended to be in the subsaturating… Expand
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Highly Cited
2002
Highly Cited
2002
Induction of cytochrome P450 3A4 (CYP3A4) is determined typically by employing primary culture of human hepatocytes and measuring… Expand
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Highly Cited
2000
Highly Cited
2000
The multidrug resistance proteins MRP1 and MRP2 are members of the same subfamily of ATP-binding cassette transporters. Besides… Expand
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Review
1998
Review
1998
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for… Expand
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Highly Cited
1988
Highly Cited
1988
Tolbutamide hydroxylation has been investigated in human liver microsomes. Anti-human liver NADPH-cytochrome P-450 reductase IgG… Expand
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Highly Cited
1988
Highly Cited
1988
To determine whether specific antiplatelet therapies improved vein graft patency after coronary artery bypass grafting (CABG) we… Expand
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Highly Cited
1985
Highly Cited
1985
We performed a randomized, double-blind, placebo-controlled trial in 555 patients with unstable angina who were hospitalized in… Expand
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Highly Cited
1983
Highly Cited
1983
The effect of sulfinpyrazone on endothelial injury induced by homocysteine has been studied both in vitro, using cultured human… Expand
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Highly Cited
1978
Highly Cited
1978
  • The New England journal of medicine
  • 1978
  • Corpus ID: 10267616
Five hundred and eighty-five patients with threatened stroke were followed in a randomized clinical trial for an average of 26… Expand
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