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Substantia nigra structure

Known as: Substantia nigra, Nucleus of basis pedunculi, Nigras, Substantia 
A large cell mass extending forward, over the dorsal surface of the crus cerebri, from the rostral border of the pons into the subthalamic region. It… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (1)

Basal Ganglia
Blood supply aspectsBody partBrainCDISC SDTM Anatomical Location Terminology

Narrower (1)

Pars Compacta

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons in the substantia… 
Highly Cited
2004
Highly Cited
2004
The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
Familial parkinsonism and dementia with cortical and subcortical Lewy bodies is uncommon, and no genetic defect has been reported… 
Review
2003
Review
2003
Parkinson's Disease Mechanisms and Models
Highly Cited
1998
Highly Cited
1998
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Parkinson's disease is a common neurodegenerative disease with complex clinical features. Autosomal recessive juvenile… 
Review
1992
Review
1992
Reactive Oxygen Species and the Central Nervous System
Abstract: Radicals are species containing one or more unpaired electrons, such as nitric oxide (NO•−). The oxygen radical… 
Highly Cited
1991
Highly Cited
1991
Ageing and Parkinson's disease: substantia nigra regional selectivity.
The micro-architecture of the substantia nigra was studied in control cases of varying age and patients with parkinsonism. A… 
Highly Cited
1990
Highly Cited
1990
D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons.
The striatum, which is the major component of the basal ganglia in the brain, is regulated in part by dopaminergic input from the… 
Review
1988
Review
1988
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
  • W. Gibb, A. Lees
  • Journal of neurology, neurosurgery, and…
  • 1988
  • Corpus ID: 15172915
The Lewy body is a distinctive neuronal inclusion that is always found in the substantia nigra and other specific brain regions… 
Highly Cited
1988
Highly Cited
1988
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the… 
Highly Cited
1983
Highly Cited
1983
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.
Four persons developed marked parkinsonism after using an illicit drug intravenously. Analysis of the substance injected by two… 
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