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Stromal Interaction Molecules

Known as: Stromal Interaction Molecules [Chemical/Ingredient] 
Membrane-associated calcium-binding proteins that are characterized by N-terminal EF HAND MOTIFS and a STERILE ALPHA MOTIF. They function as sensors… 
National Institutes of Health

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In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity.
Review
2016
Review
2016
The store-operated Ca(2+) entry-mediated signaling is important for cancer spread.
Review
2015
Review
2015
STIM and ORAI proteins in the nervous system
Stromal interaction molecules (STIM) 1 and 2 are sensors of the calcium concentration in the endoplasmic reticulum. Depletion of… 
Review
2012
Review
2012
Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity
Abstract  Store‐operated Ca2+ entry (SOCE) in cells of the immune system is mediated by Ca2+ release‐activated Ca2+ (CRAC… 
Review
2012
Review
2012
Physiological and pathophysiological functions of SOCE in the immune system.
Calcium signals play a critical role in many cell-type specific effector functions during innate and adaptive immune responses… 
Highly Cited
2011
Highly Cited
2011
Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry
Stromal interaction molecules (STIM)s function as endoplasmic reticulum calcium (Ca2+) sensors that differentially regulate… 
Highly Cited
2010
Highly Cited
2010
T‐cell‐specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells
T‐cell function is dependent on store‐operated Ca2+ influx that is activated by the stromal interaction molecules (STIM) 1 and 2… 
Review
2010
Review
2010
Partial unfolding and oligomerization of stromal interaction molecules as an initiation mechanism of store operated calcium entry.
Spatiotemporally discrete cytoplasmic Ca2+ fluctuations are fundamental eukaryotic signals in myriad physiological and… 
Highly Cited
2009
Highly Cited
2009
Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics*
Stromal interaction molecules (STIM) 1 and STIM2 are regulators of store-operated calcium (Ca2+) entry as well as basal… 
Highly Cited
2009
Highly Cited
2009
Stromal Interaction Molecules 1 and 2 Are Key Regulators of Autoreactive T Cell Activation in Murine Autoimmune Central Nervous System Inflammation
Calcium (Ca2+) signaling in T lymphocytes is essential for a variety of functions, including the regulation of differentiation… 
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