Sprouty-Related, EVH1 Domain-Containing Protein 1

Known as: Spred-1, Suppressor of Ras/MAPK Activation, hSpred1 
Sprouty-related, EVH1 domain-containing protein 1 (444 aa, ~50 kDa) is encoded by the human SPRED1 gene. This protein plays a role in signal… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2015
012320032015

Papers overview

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2015
2015
Aging research is currently focusing on circulating functional markers that can help discriminate the mechanisms of physiological… (More)
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2009
2009
This study demonstrates that CD8+ T cells in the tumor microenvironment display reduced functionality and hyporesponsiveness. TGF… (More)
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Highly Cited
2007
Highly Cited
2007
Spred/Sprouty family proteins negatively regulate growth factor-induced ERK activation. Although the individual physiological… (More)
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2006
2006
Spred proteins modulate growth factor receptor signaling by inhibiting the Ras-MAPK cascade. Here, we show that Spred-1, Spred-2… (More)
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2005
2005
T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play a critical role in allergic asthma. These cytokines… (More)
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2005
2005
Caveolin-1 (Cav-1) has been suggested to function as a negative regulator of mitogen-stimulated proliferation and the Ras-p42/44… (More)
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2005
2005
Sprouty and Spred {Sprouty-related EVH1 [Ena/VASP (vasodilator-stimulated phosphoprotein) homology 1] domain} proteins have been… (More)
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2004
2004
Sprouty/Spred family proteins have been identified as negative regulators of growth factor-induced ERK/mitogen-activated protein… (More)
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2004
2004
Spred-1 and Spred-2 (Sprouty-related protein with an EVH1 domain) are recently described members of the EVH1 (Ena/VASP-homology… (More)
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2003
2003
We have reported on Spred-1 and Spred-2, which inhibit MAP kinase activation by interacting with c-kit and ras/raf. Here, we… (More)
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