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Sphingomyelin Phosphodiesterase 2

Known as: Lyso-Platelet-Activating Factor-Phospholipase C, Lyso-PAF-PLC, EC 3.1.4.12 
Sphingomyelin phosphodiesterase 2 (423 aa, ~48 kDa) is encoded by the human SMPD2 gene. This protein is involved in phospholipid metabolism.
National Institutes of Health

Papers overview

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2015
2015
BACKGROUND & AIMS Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, hepatocyte ballooning… Expand
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2013
2013
BackgroundCeramide accumulation is considered a contributing factor to neuronal dysfunction and damage. However, the underlying… Expand
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2010
2010
PURPOSE To evaluate the effect of irradiation on microvascular endothelial cells in miniature pig parotid glands. METHODS AND… Expand
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2010
2010
Fabry disease is a genetic disease caused by a deficiency of alpha-galactosidase A (GLA), which leads to systemic accumulation of… Expand
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2008
2008
Endoplasmic reticulum (ER) stress induces INS-1 cell apoptosis by a pathway involving Ca(2+)-independent phospholipase A(2) (iPLA… Expand
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Highly Cited
2007
Highly Cited
2007
Crocus sativus L. (saffron) has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional… Expand
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Highly Cited
2007
Highly Cited
2007
We recently described a new route for the synthesis of phosphatidylethanolamine (PtdEtn) from exogenous lyso-PtdEtn, which we… Expand
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2007
2007
Oxidative stress and inflammation are fundamental for the onset of aging and appear to be causatively linked. Previously, we… Expand
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Highly Cited
2005
Highly Cited
2005
Aging is the single most important risk factor for AD (Alzheimer's disease). However, the molecular events that connect normal… Expand
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Highly Cited
2004
Highly Cited
2004
Human immunodeficiency virus type 1 (HIV-1) infection is known to cause disorders of the CNS, including HIV-associated dementia… Expand
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