Sphingomyelin Phosphodiesterase 2

Known as: Lyso-Platelet-Activating Factor-Phospholipase C, Lyso-PAF-PLC, EC 3.1.4.12 
Sphingomyelin phosphodiesterase 2 (423 aa, ~48 kDa) is encoded by the human SMPD2 gene. This protein is involved in phospholipid metabolism.

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Topic mentions per year

1989-2017
02419892017

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2014
2014
AIMS A variety of vessels, such as resistance pulmonary arteries (PA) and fetoplacental arteries and the ductus arteriosus (DA… (More)
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2013
2013
Thrombin activates platelets mainly through protease-activated receptor (PAR)1 and PAR4. However, downstream platelet signaling… (More)
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2005
2005
Thalidomide, which is clinically recognized as an efficient therapeutic agent for multiple myeloma, has been thought to exert… (More)
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2005
2005
Aging is the single most important risk factor for AD (Alzheimer's disease). However, the molecular events that connect normal… (More)
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2005
2005
Although accumulating evidence demonstrates that white matter degeneration contributes to pathology in Alzheimer's disease (AD… (More)
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2005
2005
Amyloid beta-peptide (Abeta) is a major constituent of senile plaques in the brains of Alzheimer's disease (AD) patients. We have… (More)
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2004
2004
Lipopolysaccharide (LPS) and interferon-gamma (IFN) treatment of C6 rat glioma cells increased the intracellular ceramide level… (More)
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Highly Cited
2003
Highly Cited
2003
Resveratrol (3,4',5-trans-trihydroxystilbene), a phytoalexin present in grapes and red wine, is emerging as a natural compound… (More)
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2003
2003
Neutral sphingomyelinase (N-SMase) is one of the key enzymes involved in the generation of ceramide; however, the gene(s… (More)
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2002
2002
Sphingomyelin is a major lipid in the bilayer of subcellular membranes of eukaryotic cells. Different sphingomyelinases catalyze… (More)
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