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Sphingomyelin Phosphodiesterase 2

Known as: Lyso-Platelet-Activating Factor-Phospholipase C, Lyso-PAF-PLC, EC 3.1.4.12 
Sphingomyelin phosphodiesterase 2 (423 aa, ~48 kDa) is encoded by the human SMPD2 gene. This protein is involved in phospholipid metabolism.
National Institutes of Health

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Related topics

10 relations
Enzyme GeneEsterase GeneHydrolaseHydrolysis

Papers overview

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2015
2015
Effects of ceramide pathway inhibition on the inflammatory response in lipopolysacharide-triggered lung injury
Background: Ceramide participate in various pathophysiologic events in ARDS and can be formed through several pathways. Otherwise… 
2015
2015
Characterization of ceramide generation kinetics in a lung injury model induced by lipopolysaccharide
Background: Ceramide participate in various pathophysiologic events in ARDS and can be formed through several pathways. The… 
2010
2010
Roles of Neutral Sphingomyelinase 1 on CD95-Mediated Apoptosis in Human Jurkat T Lymphocytes
Abstract － CD95 receptor is a member of tumor necrosis factor receptor family that mediates apoptosis in many cell types when… 
2007
2007
新規酵素 lyso-PAF acetyltransferase と LPC acyltransferase の解析
2004
2004
27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells.
2003
2003
Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase.
Deprenyl and benzofenone-type congeners of alpha-mangostin 1 have been synthesized to understand their role for the inhibitory… 
2000
2000
Effects of cardiac natriuretic peptides on oxidized low-density lipoprotein- and lysophosphatidylcholine-induced human mesangial cell migration.
The objectives of the present study were (1) to determine whether oxidized LDL and lysophosphatidylcholine (lyso-PtdCho), a major… 
1989
1989
Metabolism of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by cultured rat Kupffer cells.
The metabolism of platelet-activating factor (PAF; identified as AGEPC: 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso… 
1989
1989
Platelet-activating factor causes goblet cell depletion in the conjunctiva.
1988
1988
Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart.
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