Somatic Hypermutation, Immunoglobulin

Known as: Ig Somatic Hypermutations, Somatic Hypermutation, Ig, Hypermutation, Ig Somatic 
A programmed mutation process whereby changes are introduced to the nucleotide sequence of immunoglobulin gene DNA during development.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during an immune response… (More)
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Review
2008
Review
2008
Affinity maturation of the humoral response is mediated by somatic hypermutation of the immunoglobulin (Ig) genes and selection… (More)
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Highly Cited
2004
Highly Cited
2004
Activation-induced cytidine deaminase (AID) is a single-stranded (ss) DNA deaminase required for somatic hypermutation (SHM) and… (More)
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Highly Cited
2003
Highly Cited
2003
Activation-induced cytidine deaminase (AID) is a protein required for B cells to undergo class switch recombination and somatic… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND We have previously proposed that deamination of cytosine to uracil at sites within the immunoglobulin loci by… (More)
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Review
2002
Review
2002
Somatic hypermutation is critical for the generation of high-affinity antibodies and effective immune responses, but its… (More)
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Review
2002
Review
2002
Class switch recombination (CSR) and somatic hypermutation (SHM) have been considered to be mediated by different molecular… (More)
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Highly Cited
2001
Highly Cited
2001
Genomic instability promotes tumorigenesis and can occur through various mechanisms, including defective segregation of… (More)
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Highly Cited
2000
Highly Cited
2000
How rearranged immunoglobulin (Ig) genes are further diversified by somatic hypermutation is unknown. Using VDJ passenger Ig… (More)
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Review
1995
Review
1995
For the generation of secondary response antibodies, immunoglobulin genes are subjected to hypermutation. Cells expressing… (More)
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