Solute Carrier Family 22 Member 2

Known as: Organic Cation Transporter 2 
Solute carrier family 22 member 2 (555 aa, ~63 kDa) is encoded by the human SLC22A2 gene. This protein is involved in mediating tubular uptake of… (More)
National Institutes of Health

Papers overview

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2015
2015
Acute kidney injury (AKI) is a potentially fatal syndrome characterized by a rapid decline in kidney function caused by ischemic… (More)
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2013
2013
Vandetanib was evaluated as an inhibitor of human organic anion transporter 1 (OAT1), OAT3, organic cation transporter 2 (OCT2… (More)
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2013
2013
Genome-wide association studies reported SLC22A2 variants to be associated with serum creatinine. As SLC22A2 encodes the organic… (More)
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Review
2012
Review
2012
Transporters are important mediators of specific cellular uptake and thus, not only for effects, but also for side effects… (More)
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2012
2012
Susceptibility to cisplatin (CDDP) nephrotoxicity is known to vary between individuals, but the basis of this variation has not… (More)
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2010
2010
Recent studies provided strong evidence to suggest that organic cation transporter 2 (OCTN2) is a direct target gene of… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE The goal of this study was to determine the effect of a genetic variant in the organic cation transporter 2 (OCT2… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE Cisplatin is predominantly eliminated in the urine through active secretion. As the solute carrier organic cation… (More)
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2000
2000
The organic cation transporter 2 (OCT2) is expressed in plasma membranes of kidney and brain. Its transport mechanism and… (More)
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Highly Cited
1999
Highly Cited
1999
We have demonstrated in the present study that novel organic cation transporter (OCTN) 2 is a transporter for organic cations as… (More)
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