Soluble Guanylate Cyclase, human

Known as: GUCY, Soluble Guanylate Cyclase, EC 4.6.1.2 
Human Soluble Guanylate Cyclases (Adenylyl Cyclase 4/Guanylyl Cyclase Family) are heterodimeric (alpha/beta) nitric oxide-activated cytoplasmic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2017
010020030019682017

Papers overview

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Highly Cited
2007
Highly Cited
2007
Soluble guanylate cyclase is a heterodimeric enzyme with a prosthetic heme group that, on binding of its main ligand, NO… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Severe pulmonary hypertension is a disabling disease with high mortality, characterized by pulmonary vascular… (More)
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Highly Cited
2002
Highly Cited
2002
Angiotensin II infusion causes endothelial dysfunction by increasing NAD(P)H oxidase-mediated vascular superoxide production… (More)
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Highly Cited
2001
Highly Cited
2001
Carbon monoxide (CO) can arrest cellular respiration, but paradoxically, it is synthesized endogenously by heme oxygenase type 1… (More)
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Highly Cited
2001
Highly Cited
2001
Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological and pathophysiological roles. Research… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Endothelial dysfunction of the peripheral vasculature is a well-known phenomenon in congestive heart failure that… (More)
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1998
1998
Soluble guanylate cyclase (sGC), a heterodimeric (alpha/beta) haem protein that converts GTP to the second messenger cGMP… (More)
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Highly Cited
1996
Highly Cited
1996
Heme oxygenase 2 (HO-2), which synthesizes carbon monoxide (CO), has been localized by immunohistochemistry to endothelial cells… (More)
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Highly Cited
1992
Highly Cited
1992
The NADPH-diaphorase histochemical technique provides a simple and robust method to stain select populations of neurons… (More)
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Highly Cited
1992
Highly Cited
1992
Nitric oxide synthases (NOS Types I-III) generate nitric oxide (NO), which in turn activates soluble guanylyl cyclase (GC-S). The… (More)
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