Sodium Dichloroacetate

Known as: Dichloroacetate, Sodium, Dichloroacetic Acid, Sodium Salt 
The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
The "Warburg effect," also termed aerobic glycolysis, describes the increased reliance of cancer cells on glycolysis for ATP… (More)
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2010
2010
We examined the effect of hypoxia on apoptosis of human colorectal cancer (CRC) cells in vitro and in vivo. All cell lines tested… (More)
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1996
1996
Sodium dichloroacetate (DCA) is a drug with potential for treating patients with stroke and head injury. Conflicting evidence has… (More)
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Highly Cited
1995
Highly Cited
1995
We performed a short-term, double-blind, placebo-controlled, crossover trial of sodium dichloroacetate (DCA) therapy in 11… (More)
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Highly Cited
1994
Highly Cited
1994
OBJECTIVES The purpose of this study was to determine whether sodium dichloroacetate improves hemodynamic performance and… (More)
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Highly Cited
1992
Highly Cited
1992
BACKGROUND Mortality is very high in lactic acidosis, and there is no satisfactory treatment other than treatment of the… (More)
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1991
1991
We report a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes who experienced visual… (More)
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1984
1984
The total activity of pyruvate dehydrogenase (PDH) complex in rat hind-limb muscle mitochondria was 76.4 units/g of mitochondrial… (More)
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1974
1974
1. Sodium dichloroacetate (300mg/kg body wt. per h) was infused in 24h-starved rats for 4h. 2. Blood glucose decreased… (More)
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1973
1973
1. The extractions of glucose, lactate, pyruvate and free fatty acids by dog heart in vivo were calculated from measurements of… (More)
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