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Sodium Dichloroacetate

Known as: Dichloroacetate, Sodium, Dichloroacetic Acid, Sodium Salt 
The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

DichloroacetateDichloroacetic Acid
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Potential role of NHE1 (sodium-hydrogen exchanger 1) in the cellular dysfunction of lactic acidosis: implications for treatment.
The development of lactic acidosis in seriously ill patients often is accompanied by impairment in organ function and increased… 
Review
2010
Review
2010
The Dichloroacetate Dilemma: Environmental Hazard versus Therapeutic Goldmine—Both or Neither?
Background Dichloroacetate (DCA) is known to environmental scientists as a by-product of water chlorination and as a metabolite… 
1999
1999
Proton magnetic resonance spectroscopy to study the metabolic changes in the brain of a patient with Leigh syndrome
1997
1997
Determination of dichloroacetate and its metabolites in human plasma by gas chromatography-mass spectrometry.
1991
1991
Therapeutic Effect of Sodium Dichloroacetate on Visual and Auditory Hallucinations in a Patient with MELAS
We report a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes who experienced visual… 
Highly Cited
1985
Highly Cited
1985
Plasma concentrations and metabolic effects of intravenous sodium dichloroacetate
Eleven healthy subjects received five doses of intravenous sodium dichloroacetate (DCA) at 2‐hr intervals. Determinations of DCA… 
Highly Cited
1980
Highly Cited
1980
Biological disposition of sodium dichloroacetate in animals and humans after intravenous administration.
Sodium dichloroacetate, a potential antidote for lactic acidosis, was administered intravenously to rats, dogs, and four humans… 
1978
1978
Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cells.
1975
1975
Metabolic interactions of dichloroacetate and insulin in experimental diabetic ketoacidosis.
1. The infusion of sodium dichloroacetate into rats with severe diabetic ketoacidosis over 4h caused a 2mM decrease in blood… 
Highly Cited
1974
Highly Cited
1974
The metabolic effects of sodium dichloroacetate in the starved rat.
1. Sodium dichloroacetate (300mg/kg body wt. per h) was infused in 24h-starved rats for 4h. 2. Blood glucose decreased… 
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