Sodium Channel Blockers

Known as: Inhibitors, Sodium Channel, Sodium Channel Inhibitors, Channel Blockers, Sodium 
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Voltage-gated sodium (Nav) channels play a fundamental role in the generation and propagation of electrical impulses in excitable… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Patients carrying the cardiac sodium channel (SCN5A) mutation 1795insD show sudden nocturnal death and signs of… (More)
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Highly Cited
2005
Highly Cited
2005
Loss of axons is a major contributor to nonremitting deficits in the inflammatory demyelinating disease multiple sclerosis (MS… (More)
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Highly Cited
2005
Highly Cited
2005
Voltage-gated sodium (Na+) channels are targets for local anesthetic (LA) drugs that bind in the inner pore of the channel with… (More)
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Highly Cited
2003
Highly Cited
2003
Transcranial direct current stimulation (tDCS) of the human motor cortex results in polarity-specific shifts of cortical… (More)
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Highly Cited
2001
Highly Cited
2001
Diffuse axonal injury (DAI) is one of the most common and important pathologies resulting from the mechanical deformation of the… (More)
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Highly Cited
1996
Highly Cited
1996
A long-standing question in neurobiology is whether astrocytes respond to the neuronal release of neurotransmitters in vivo. To… (More)
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Highly Cited
1995
Highly Cited
1995
Simultaneous somatic and dendritic recordings were made from the same neocortical layer V pyramidal neuron, and current injection… (More)
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Highly Cited
1995
Highly Cited
1995
To investigate whether local anesthetic neurotoxicity results from sodium channel blockade, we compared the effects of… (More)
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Highly Cited
1979
Highly Cited
1979
A voltage clamp technique was used to study sodium currents and gating currents in squid axons internally perfused with the… (More)
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