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Sodium Channel Antagonists [MoA]

Known as: Sodium Channel Antagonists, Sodium Channel Blockers 
 
National Institutes of Health

Papers overview

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2019
2019
PURPOSE A number of antiepileptic drugs (AEDs) with a variety of modes of action, are effective in treating focal seizures… Expand
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2016
2016
Palmyrolide A is a neuroprotective macrolide isolated by Gerwick and coworkers in 2010. This natural product is known to suppress… Expand
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Review
2014
Review
2014
Introduction: Migraine has a strong social impact, influencing both quality of life and work productivity. Therapeutic approach… Expand
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2011
2011
Sodium channel inhibition is a well precedented mechanism used to treat epilepsy and other hyperexcitability disorders. The… Expand
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2010
2010
A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Na(v)1.8 sodium channel is… Expand
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2009
2009
Disulfide bridges that stabilize the native conformation of conotoxins pose a challenge in the synthesis of smaller conotoxin… Expand
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2008
2008
1-Benzyl-N-(2,6-dimethylphenyl)piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide, two… Expand
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2004
2004
Hainantoxin-IV (HNTX-IV) can specifically inhibit the neuronal tetrodotoxin-sensitive sodium channels and defines a new class of… Expand
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2001
2001
Excessive glutamatergic neurotransmission, particularly when mediated by the N:-methyl-D-aspartate (NMDA) subtype of glutamate… Expand
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Review
1996
Review
1996
In epilepsy research, there is growing interest in the role of the piriform cortex (PC) in the development and maintenance of… Expand
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