Sodium Channel Antagonists [MoA]

Known as: Sodium Channel Antagonists, Sodium Channel Blockers 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
012319982018

Papers overview

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2016
2016
A series of chalcones of thiazole and thiazolidinone (3a–3j) were synthesized, characterized and evaluated for anticonvulsant… (More)
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Review
2014
Review
2014
INTRODUCTION Migraine has a strong social impact, influencing both quality of life and work productivity. Therapeutic approach of… (More)
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2014
2014
A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized and displayed potent Nav1.7 inhibitory activity and moderate… (More)
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2013
2013
OBJECTIVES The conformational state of voltage-gated sodium channels is an important determinant for the efficacy of both local… (More)
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2011
2011
Sodium channel inhibition is a well precedented mechanism used to treat epilepsy and other hyperexcitability disorders. The… (More)
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2008
2008
The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is… (More)
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2008
2008
A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential… (More)
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2006
2006
Novel cyclopentane-based 3-phenyl-1-hydroxypropyl compounds were evaluated for inhibitory activity against the peripheral nerve… (More)
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2004
2004
A series of 3-(4-phenoxyphenyl)-1H-pyrazoles were synthesized and characterized as potent state-dependent sodium channel blockers… (More)
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1998
1998
Synthesis and structure-activity relationships (SAR) are described for a series of N,N'-diarylguanidines related to N-acenaphth-5… (More)
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