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Sodium Channel Antagonists [MoA]

Known as: Sodium Channel Antagonists, Sodium Channel Blockers 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
PURPOSE A number of antiepileptic drugs (AEDs) with a variety of modes of action, are effective in treating focal seizures… Expand
2016
2016
Palmyrolide A is a neuroprotective macrolide isolated by Gerwick and coworkers in 2010. This natural product is known to suppress… Expand
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Review
2014
Review
2014
Introduction: Migraine has a strong social impact, influencing both quality of life and work productivity. Therapeutic approach… Expand
2010
2010
A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Na(v)1.8 sodium channel is… Expand
2009
2009
Transforming the neuroactive toxins of cone snails into small‐size compounds poses a challenge due to the presence of multiple… Expand
2008
2008
1-Benzyl-N-(2,6-dimethylphenyl)piperidine-3-carboxamide and 4-benzyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide, two… Expand
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Highly Cited
2004
Highly Cited
2004
Hainantoxin-IV (HNTX-IV) can specifically inhibit the neuronal tetrodotoxin-sensitive sodium channels and defines a new class of… Expand
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2004
2004
A series of 3-(4-phenoxyphenyl)-1H-pyrazoles were synthesized and characterized as potent state-dependent sodium channel blockers… Expand
Highly Cited
2001
Highly Cited
2001
Excessive glutamatergic neurotransmission, particularly when mediated by the N‐methyl‐d‐aspartate (NMDA) subtype of glutamate… Expand
Review
1996
Review
1996
In epilepsy research, there is growing interest in the role of the piriform cortex (PC) in the development and maintenance of… Expand