Smac Mimetic GDC-0917

Known as: GDC-0917, IAP Antagonist GDC-0917, SMAC/DIABLO Mimetic GDC-0917 
An orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
0246819772017

Papers overview

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2016
2016
Birinapant is a smac-mimetic (SM) in clinical trials for treating cancer. SM antagonize inhibitor of apoptosis (IAP) proteins and… (More)
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2016
2016
SMAC-mimetics represent a targeted therapy approach to overcome apoptosis resistance in many tumors. Here, we investigated the… (More)
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2016
2016
High expression levels of Inhibitors of Apoptosis Proteins (IAPs) have been correlated with poor cancer prognosis and block the… (More)
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2015
2015
BACKGROUND The mainstay of treatment in rectal cancer is neoadjuvant radio chemotherapy prior to surgery, in an attempt to… (More)
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2015
2015
The discovery of cancer cell-selective tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis… (More)
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2014
2014
Resistance to apoptosis is a hallmark of cancer, and represents an important mechanism of how tumor cells resist immune cell… (More)
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2013
2013
The application of modeling and simulation techniques is increasingly common in the preclinical stages of the drug development… (More)
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2010
2010
BACKGROUND & AIMS Factors that regulate enterocyte apoptosis in necrotizing enterocolitis (NEC) remain incompletely understood… (More)
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2009
2009
Smac mimetics (SM) have been recently reported to kill cancer cells through the extrinsic apoptosis pathway mediated by autocrine… (More)
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2008
2008
Drug resistance is a major concern in cancer therapy. Here, we investigate the clinical potential of the second mitochondria… (More)
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