Skip to search formSkip to main contentSkip to account menu

Smac Mimetic GDC-0917

Known as: GDC-0917, IAP Antagonist GDC-0917, SMAC/DIABLO Mimetic GDC-0917 
An orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of… 
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics
There is a need for novel strategies to initiate cancer cell death. One approach is the use of Smac mimetics, which antagonize… 
2015
2015
Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.
Review
2013
Review
2013
Emerging role of the ubiquitin-proteasome system as drug targets.
The ubiquitin-proteosome system (UPS) regulates a wide range of cellular processes including protein degradation, DNA repair… 
2012
2012
LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling.
Smac mimetics block inhibitor of apoptosis proteins to trigger TNFα-dependent apoptosis in cancer cells. However, only a small… 
2011
2011
Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization.
2010
2010
Theoretical studies on the interactions of XIAP-BIR3 domain with bicyclic and tricyclic core monovalent Smac mimetics.
2007
2007
Rapid induction of IAP family proteins and Smac/DIABLO expression after proapoptotic stimulation with doxorubicin in RPMI 8226 multiple myeloma cells.
Highly Cited
2002
Highly Cited
2002
Promotion of Photodynamic Therapy-Induced Apoptosis by the Mitochondrial Protein Smac/DIABLO: Dependence on Bax¶
Abstract Photodynamic therapy (PDT) using the second-generation photosensitizer phthalocyanine (Pc) 4 causes mitochondrial damage… 
Highly Cited
1986
Highly Cited
1986
The method of determination must be considered in interpreting blood cholesterol levels.
Based on the results of recent clinical trials, physicians have been encouraged to screen and treat patients for… 
1978
1978
Pitfalls of use of lipemic serum with the Technicon SMAC and Du Pont aca.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)