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Sialic Acid Binding Ig-like Lectin 1

Known as: Sialoadhesin, CD169 Antigens, Siglec-1 
A sialic acid binding lectin that was originally identified as an adhesion molecule for inflammatory MACROPHAGES and activated MONOCYTES. This… 
National Institutes of Health

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In BloodProcess of secretionSIGLEC1 geneagonists

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SIGLEC1 protein, human

Papers overview

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2015
2015
Prognostic Signi fi cance of CD 169 þ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma
CD169 (sialoadhesin) is a sialic acid receptor that is specifically expressed on macrophages, including lymph node sinus… 
2015
2015
FRI0375 Flow-Based Cell-Specific Interferon Signature as a Biomarker in Systemic Lupus Erythematosus
Background Type I interferons (IFNs) have been confirmed to play a pivotal role in the pathogenesis of Systemic lupus… 
2014
2014
A3.26 Proteasome inhibition with bortezomib in refractory SLE inhibits type I interferon and depletes plasma cells but does not inhibit their regeneration
Background The proteasome inhibitor bortezomib, approved for the treatment of multiple myeloma, has been demonstrated to deplete… 
2013
2013
Phenotypic change of macrophages in the progression of diabetic nephropathy; sialoadhesin-positive activated macrophages are increased in diabetic kidney
2013
2013
Interactions between siglec-1+ macrophages and dendritic cells: opportunities for anti-melanoma immunotherapy
2011
2011
PRRSV binding to and/or internalization by its receptor sialoadhesin on macrophages is sufficient to compromise phagocytosis
2008
2008
Real-time quantitative RT-PCR in measuring Siglec-1 gene expression levels in peripheral blood mononuclear cells of patients with coronary heart disease
Objective:To establish a real-time quantitative reverse transcription polymerase chain reaction(RT-PCR)method for examining the… 
2007
2007
Sialoadhesin (Siglec-1), a unique macrophage entry portal for targeted delivery of antigens and drugs
2005
2005
Sialoadhesin: a macrophage receptor involved in binding sialic acid-bearing xenogeneic cells and viruses
2001
2001
Adhesion Receptor Sialoadhesin (Siglec-1) Counterreceptor for the Macrophage Cutting Edge: CD43 Functions as a T Cell
Sialoadhesin (Siglec-1) is a macrophage-restricted sialic acid-binding receptor that mediates interactions with hemopoietic cells…