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Shc Signaling Adaptor Proteins

Known as: Shc Family Adapter Proteins, Shc Adaptor Proteins, Adaptor Proteins, Shc 
A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL… Expand
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Shc (Src homology and collagen homology) proteins are considered prototypical signalling adaptors in mammalian cells. Consisting… Expand
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Highly Cited
2002
Highly Cited
2002
We determined the gene structure of the human TrkB gene. The gene is unusually large and spans at least 590 kbp. It contains 24… Expand
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Highly Cited
2002
Highly Cited
2002
β-Amyloid precursor protein (APP) is a widely expressed transmembrane protein of unknown function that is involved in the… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT Neurotrophins are key regulators of the fate and shape of neuronal cells and act as guidance cues for growth cones by… Expand
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Review
2000
Review
2000
The Met receptor tyrosine kinase is the prototypic member of a small subfamily of growth factor receptors that when activated… Expand
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Highly Cited
2000
Highly Cited
2000
The receptor for insulin-like growth factor 1 (IGF-1) mediates multiple cellular responses, including stimulation of both… Expand
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Highly Cited
1998
Highly Cited
1998
The Shc adapter protein is ubiquitously expressed and has been implicated in phosphotyrosine signalings following a variety of… Expand
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Highly Cited
1996
Highly Cited
1996
We have used the yeast two-hybrid system to study the interaction between the IGF-I receptor and two putative substrates, IRS-1… Expand
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Highly Cited
1996
Highly Cited
1996
Protein tyrosine phosphorylation events play determinant roles in cellular processes such as proliferation and differentiation… Expand
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Highly Cited
1996
Highly Cited
1996
Germ line mutations of the ret proto-oncogene are associated with the development of three dominantly inherited neoplastic… Expand
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