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ShK neurotoxin

Known as: ShK toxin 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Cnidarian VenomsPotassium Channel Blockers

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells
Shikonin (SHK) has been proven to have a good anti-tumor effect. However, poor water solubility and low bioavailability limit its… Expand
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2017
2017
Prognostic power of global 2D strain according to left ventricular ejection fraction in patients with ST elevation myocardial infarction
Backgrounds We aimed to evaluate the predictive power of longitudinal and circumferential fibers according to left ventricular… Expand
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2014
2014
Detection of Human Papillomavirus Infection and p16 Immunohistochemistry Expression in Bladder Cancer with Squamous Differentiation
Objectives To determine the potential association between HPV infection and the squamous cell component of urothelial carcinoma… Expand
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2014
2014
Cross Talk with Hematopoietic Cells Regulates the Endothelial Progenitor Cell Differentiation of CD34 Positive Cells
Introduction Despite the crucial role of endothelial progenitor cells (EPCs) in vascular regeneration, the specific interactions… Expand
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2007
2007
Molecular Mechanism of the Sea Anemone Toxin ShK Recognizing the Kv1.3 Channel Explored by Docking and Molecular Dynamic Simulations
Computational methods are employed to simulate the interaction of the sea anemone toxin ShK in complex with the voltage-gated… Expand
Review
2004
Review
2004
Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases.
Expression of the two lymphocyte potassium channels, the voltage-gated channel Kv1.3 and the calcium activated channel IKCa1… Expand
2003
2003
Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.
ShK, a peptide isolated from Stichodactyla helianthus venom, blocks the voltage-gated potassium channels, K(v)1.1 and K(v)1.3… Expand
Highly Cited
2002
Highly Cited
2002
Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.
The voltage-gated potassium channel in T lymphocytes, Kv1.3, an important target for immunosuppressants, is blocked by picomolar… Expand
Highly Cited
2001
Highly Cited
2001
Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis
Adoptive transfer experimental autoimmune encephalomyelitis (AT-EAE), a disease resembling multiple sclerosis, is induced in rats… Expand
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Highly Cited
1998
Highly Cited
1998
ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide*
The voltage-gated potassium channel in T lymphocytes, Kv1.3, is an important molecular target for immunosuppressive agents. A… Expand
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