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Serine/Threonine Protein Kinase NIK

Known as: NF-Kappa-Beta-Inducing Kinase, NFKB-Inducing Kinase, MAP3K14 Protein 
Mitogen-activated protein kinase kinase kinase 14 (947 aa, ~104 kDa) is encoded by the human MAP3K14 gene. This protein is involved in both serine… 
National Institutes of Health

Related topics

Related topics

33 relations
ApoptosisB-Cell Immune Response PathwayCD40L Signaling PathwayColon structure (body structure)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A pathway‐based association analysis identified FMNL1‐MAP3K14 as susceptibility genes for leprosy
The nuclear transcription factor‐κB (NF‐κB) plays a pivotal role in controlling both innate and adaptive immunity and regulates… 
2017
2017
Morinda citrifolia Leaf Extract Suppressed Metastasised Cancer Progression via EGFR and MAPK Pathways
Abstract Morinda citrifolia leaf has anti-inflammatory and immune enhancing effects against lung cancer. The effects of the… 
2017
2017
Simulation of the dynamics of primary immunodeficiencies in CD4+ T-cells
Primary immunodeficiencies (PIDs) form a large and heterogeneous group of mainly rare disorders that affect the immune system. T… 
2014
2014
NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells
IL-5 plays important roles in eosinophil differentiation, expansion, and recruitment. The regulation of IL-5 seems critical for… 
2010
2010
A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference.
Highly Cited
2008
Highly Cited
2008
Respiratory Syncytial Virus Induces RelA Release from Cytoplasmic 100-kDa NF-κB2 Complexes via a Novel Retinoic Acid-inducible Gene-I·NF-κB-inducing Kinase Signaling Pathway*
Respiratory syncytial virus (RSV) is a primary cause of severe lower respiratory tract infection in children worldwide. RSV… 
2005
2005
Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with NF-kappaB2.
A member of the Paramyxoviridae family of RNA viruses, respiratory syncytial virus (RSV), is a leading cause of epidemic… 
2005
2005
Signaling negative selection: is MINK the missing link?
The signaling pathways distinguishing positive and negative thymic selection are critical for establishing T cell immunity and… 
2002
2002
S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100.
Proteasome-mediated processing of the nfkappab2 gene product p100 is a regulated event that generates the NF-kappaB subunit p52… 
2000
2000
The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis.
NF-kappa B has been implicated in the survival and differentiation of PC12 cells. In this study, we examined the effect of the NF… 
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