Senile Plaques

Neuroinflammatory response is primarily a protective mechanism in the brain. However, excessive and chronic inflammatory… (More)

Alzheimer's disease (AD) is the most common cause of dementia and one of the most important causes of morbidity and mortality… (More)

Alzheimer's disease (AD) is the primary cause of age-related dementia. Effective strategies to prevent and treat AD remain… (More)

Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no therapeutic intervention is available to… (More)

Tumor necrosis factor α (TNF-α) inhibitors have long been used as disease-modifying agents in immune disorders. Recently… (More)

Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological hallmarks of Alzheimer's disease (AD… (More)

Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and… (More)

Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia… (More)

Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the… (More)

We studied the accumulation of neurofibrillary tangles (NFTs) and senile plaques (SPs) in 10 Alzheimer's disease patients who had… (More)