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Selective Estrogen Receptor Down Regulator

Known as: SERD, SERDs 
Agents that selectively bind to estrogen receptors on breast cancer cells and stop estrogen-dependent cell proliferation. (NCI)
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Mutations in ESR1 have been associated with resistance to aromatase inhibitor (AI) therapy in patients with ER+ metastatic breast… Expand
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Highly Cited
2015
Highly Cited
2015
Approximately 80% of breast cancers are estrogen receptor alpha (ER-α) positive, and although women typically initially respond… Expand
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Review
2015
Review
2015
Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered… Expand
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Highly Cited
2013
Highly Cited
2013
Endometrial carcinoma is the most common cancer of the female reproductive tract. GPER/GPR30 is a 7-transmembrane spanning G… Expand
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Highly Cited
2011
Highly Cited
2011
It has become apparent of late that even in tamoxifen and/or aromatase resistant breast cancers, ERα remains a bona fide… Expand
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Review
2011
Review
2011
Endogenous estrogens are important regulators of cardiovascular homeostasis in premenopausal women and delay the development of… Expand
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Highly Cited
2010
Highly Cited
2010
BackgroundThe estrogen receptor alpha (ERα) is found predominately in the nucleus, both in hormone stimulated and untreated cells… Expand
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Highly Cited
2007
Highly Cited
2007
One subclass of antiestrogens, the selective estrogen receptor down-regulators (SERDs), have received considerable attention of… Expand
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Review
2004
Review
2004
Tamoxifen is one of the most effective treatments for breast cancer through its ability to antagonize estrogen-dependent growth… Expand
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Highly Cited
1991
Highly Cited
1991
We describe the molecular characterization of the Drosophila gene Serrate (Ser), which encodes an integral membrane protein. The… Expand
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