Selective Estrogen Receptor Down Regulator

Known as: SERD, SERDs 
Agents that selectively bind to estrogen receptors on breast cancer cells and stop estrogen-dependent cell proliferation. (NCI)

Topic mentions per year

Topic mentions per year

1984-2018
051019842018

Papers overview

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Review
2017
Review
2017
Based on the prominent role estrogen receptor (ER) plays in breast cancer, endocrine therapy has been developed to block the ER… (More)
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2016
2016
Mutations in ESR1 have been associated with resistance to aromatase inhibitor (AI) therapy in patients with ER+ metastatic breast… (More)
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2015
2015
Estrogen receptors (ERs) play a major role in the growth of human breast cancer cells. An antagonist that acts as not only an… (More)
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2013
2013
Endometrial carcinoma is the most common cancer of the female reproductive tract. GPER/GPR30 is a 7-transmembrane spanning G… (More)
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2011
2011
It has become apparent of late that even in tamoxifen and/or aromatase resistant breast cancers, ERα remains a bona fide… (More)
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Highly Cited
2011
Highly Cited
2011
Fulvestrant is a selective estrogen receptor downregulator (SERD) and highly effective antagonist to hormone-sensitive breast… (More)
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2010
2010
The estrogen receptor alpha (ERα) is found predominately in the nucleus, both in hormone stimulated and untreated cells… (More)
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2007
2007
One subclass of antiestrogens, the selective estrogen receptor down-regulators (SERDs), have received considerable attention of… (More)
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Review
2004
Review
2004
Tamoxifen is one of the most effective treatments for breast cancer through its ability to antagonize estrogen-dependent growth… (More)
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2002
2002
This paper proposes a path-tracking algorithm to compensate for path deviation due to torque limits. The algorithm uses a… (More)
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