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SYNPO protein, human

Known as: Synaptopodin, synaptopodin protein, human 
Synaptopodin (929 aa, ~94 kDa) is encoded by the human SYNPO gene. This protein is involved in actin-mediated cell morphology and cell motility.
National Institutes of Health

Related topics

Related topics

9 relations
Cell MovementCytokinesisCytoskeletal GeneCytoskeleton

Broader (1)

Microfilament Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Microbiota-derived butyrate dynamically regulates intestinal homeostasis through regulation of actin-associated protein synaptopodin
Significance Intestinal epithelial barrier dysfunction and dysbiosis are central themes of inflammatory bowel diseases (IBDs… 
Review
2017
Review
2017
Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury
Diabetes induces the onset and progression of renal injury through causing hemodynamic dysregulation along with abnormal… 
Highly Cited
2013
Highly Cited
2013
Essential Role for Synaptopodin in Dendritic Spine Plasticity of the Developing Hippocampus
Dendritic spines are a major substrate of brain plasticity. Although many studies have focused on Ca2+/calmodulin-dependent… 
Highly Cited
2012
Highly Cited
2012
Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-κB-dependent pathway.
BACKGROUND Recent studies suggest that CD80 (also known as B7.1) is expressed on podocytes in minimal-change disease (MCD) and… 
2011
2011
Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling.
Alterations to the structure of the glomerular filtration barrier lead to effacement of podocyte foot processes, leakage of… 
2011
2011
Connective tissue growth factor modulates podocyte actin cytoskeleton and extracellular matrix synthesis and is induced in podocytes upon injury
Structural changes of podocytes and retraction of their foot processes are a critical factor in the pathogenesis of minimal… 
Review
2009
Review
2009
Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis—a review
This review deals with podocyte proteins that play a significant role in the structure and function of the glomerular filter… 
Highly Cited
2005
Highly Cited
2005
Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/α‐actinin binding protein
Synaptopodin (SYNPO) is a cytoskeletal protein that is preferentially located in mature dendritic spines, where it accumulates in… 
Highly Cited
2002
Highly Cited
2002
Interaction of Two Actin-binding Proteins, Synaptopodin and α-Actinin-4, with the Tight Junction Protein MAGI-1*
In an attempt to find podocyte-expressed proteins that may interact with the tight junction protein MAGI-1, we screened a… 
Highly Cited
2001
Highly Cited
2001
Synaptopodin expression in idiopathic nephrotic syndrome of childhood.
BACKGROUND Synaptopodin is a proline-rich protein intimately associated with actin microfilaments present in the podocytes' foot… 
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