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SYN-004

 
National Institutes of Health

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2 relations

Broader (2)

Recombinant Proteinsbeta-Lactamase

Papers overview

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2019
2019
Use of ribaxamase (SYN-004), a β-lactamase, to prevent Clostridium difficile infection in β-lactam-treated patients: a double-blind, phase 2b, randomised placebo-controlled trial.
BACKGROUND Infections with Clostridium difficile are a health threat, yet no products are currently licensed for prevention of… Expand
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2017
2017
The Oral β-Lactamase SYN-004 (Ribaxamase) Degrades Ceftriaxone Excreted into the Intestine in Phase 2a Clinical Studies
SYN-004 (ribaxamase) is a β-lactamase designed to be orally administered concurrently with intravenous β-lactam antibiotics… Expand
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2017
2017
SYN‐004 (ribaxamase), an oral beta‐lactamase, mitigates antibiotic‐mediated dysbiosis in a porcine gut microbiome model
AIM To evaluate an antibiotic inactivation strategy to protect the gut microbiome from antibiotic-mediated damage. METHODS AND… Expand
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2017
2017
Formulation development of SYN-004 (ribaxamase) oral solid dosage form, a β-lactamase to prevent intravenous antibiotic-associated dysbiosis of the colon.
SYN-004 (ribaxamase) delayed release drug product is a multi-particulate, hard capsule for oral delivery of a recombinant… Expand
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2017
2017
SYN-004 (ribaxamase) Protects the Diversity of the Gut Microbiome in Patients Receiving Intravenous Ceftriaxone Treatment
P R I M A R Y E N D P O I N T C O N C L U S I O N S The use of intravenous β-lactam antibiotics, including cephalosporins, are an… Expand
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2016
2016
Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection.
The gut microbiome, composed of the microflora that inhabit the gastrointestinal tract and their genomes, make up a complex… Expand
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2016
2016
Tolerability and Pharmacokinetics of SYN-004, an Orally Administered β-Lactamase for the Prevention of Clostridium difficile-Associated Disease and Antibiotic-Associated Diarrhea, in Two Phase 1…
BackgroundSYN-004 is an orally administered β-lactamase enzyme, designed to be given concurrently with certain intravenous… Expand
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2016
2016
Nonclinical Safety Assessment of SYN-004
SYN-004 is a first in class, recombinant β-lactamase that degrades β-lactam antibiotics and has been formulated to be… Expand
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2016
2016
SYN-004, A NOVEL STRATEGY TO PROTECT THE GUT MICROBIOME FROM THE DELETERIOUS EFFECTS OF RESIDUAL IV β-LACTAM ANTIBIOTICS
SYN-004 is a clinical stage oral β-lactamase therapy for use with intravenous (IV) β-lactam antibiotics to preserve the gut… Expand
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2015
2015
Tu2054 SYN-004, a Clinical Stage Oral Beta-Lactamase Therapy, Protects the Intestinal Microflora from Antibiotic-Mediated Damage in Humanized Pigs
Antibiotics (abx) that are excreted into the intestine, such as ceftriaxone (CRO), can damage the microflora and lead to serious… Expand
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