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SYN-004

 
National Institutes of Health

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2019
2019
BACKGROUND Infections with Clostridium difficile are a health threat, yet no products are currently licensed for prevention of… Expand
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2017
2017
SYN-004 (ribaxamase) is a β-lactamase designed to be orally administered concurrently with intravenous β-lactam antibiotics… Expand
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2017
2017
AIM To evaluate an antibiotic inactivation strategy to protect the gut microbiome from antibiotic-mediated damage. METHODS AND… Expand
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2017
2017
SYN-004 (ribaxamase) delayed release drug product is a multi-particulate, hard capsule for oral delivery of a recombinant… Expand
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2017
2017
P R I M A R Y E N D P O I N T C O N C L U S I O N S The use of intravenous β-lactam antibiotics, including cephalosporins, are an… Expand
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2016
2016
The gut microbiome, composed of the microflora that inhabit the gastrointestinal tract and their genomes, make up a complex… Expand
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2016
2016
BackgroundSYN-004 is an orally administered β-lactamase enzyme, designed to be given concurrently with certain intravenous… Expand
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2016
2016
SYN-004 is a first in class, recombinant β-lactamase that degrades β-lactam antibiotics and has been formulated to be… Expand
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2016
2016
SYN-004 is a clinical stage oral β-lactamase therapy for use with intravenous (IV) β-lactam antibiotics to preserve the gut… Expand
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2015
2015
Antibiotics (abx) that are excreted into the intestine, such as ceftriaxone (CRO), can damage the microflora and lead to serious… Expand
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