SV2A gene

Known as: SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2, SV2A 
 
National Institutes of Health

Papers overview

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2016
2016
OBJECTIVE Rapid distribution to the brain is a prerequisite for antiepileptic drugs used for treatment of acute seizures. The… (More)
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2011
2011
Levetiracetam is an FDA-approved drug used to treat epilepsy and other disorders of the nervous system. Although it is known that… (More)
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Highly Cited
2011
Highly Cited
2011
Homeostatic mechanisms are required to control formation and maintenance of synaptic connections to maintain the general level of… (More)
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2010
2010
Brivaracetam (ucb 34714; BRV), a new antiepileptic drug (AED) candidate, is a pyrrolidone derivative displaying a markedly higher… (More)
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Highly Cited
2008
Highly Cited
2008
Botulinum neurotoxin E (BoNT/E) can cause paralysis in humans and animals by blocking neurotransmitter release from presynaptic… (More)
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Highly Cited
2008
Highly Cited
2008
SV2A, a synaptic vesicle protein, has been recently identified as a binding target for levetiracetam (Keppra). The specific… (More)
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Review
2008
Review
2008
Many currently prescribed antiepileptic drugs (AEDs) act via voltage-gated sodium channels, through effects on gamma-aminobutyric… (More)
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2007
2007
This study was designed to investigate the human absorption, disposition, and mass balance of (14)C-brivaracetam, a novel high… (More)
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2005
2005
Synaptic vesicle protein 2 (SV2) is expressed in neuroendocrine cells as three homologous isoforms, SV2A, SV2B and SV2C. Ca2… (More)
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Highly Cited
2004
Highly Cited
2004
Here, we show that the synaptic vesicle protein SV2A is the brain binding site of levetiracetam (LEV), a new antiepileptic drug… (More)
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