STK11 protein, human

Known as: Polarization-Related Protein LKB1, liver kinase B1, human, LKB1 protein, human 
Serine/threonine-protein kinase STK11 (433 aa, ~49 kDa) is encoded by the human STK11 gene. This protein plays a role in signal transduction and… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Metformin, a biguanide drug commonly used to treat type-2 diabetes, has been noted to extend healthspan of nondiabetic mice, but… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2008
Review
2008
The AMP-activated protein kinase (AMPK) system is a key player in regulating energy balance at both the cellular and whole-body… (More)
  • figure 1
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Metformin is used for the treatment of type 2 diabetes because of its ability to lower blood glucose. The effects of metformin… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2006
Review
2006
Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2005
Highly Cited
2005
AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade that plays a pivotal role in energy… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Signal transduction pathways control cellular responses to stimuli, but it is unclear how molecular information is processed as a… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Mammalian target of rapamycin (mTOR) is a central regulator of protein synthesis whose activity is modulated by a variety of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2004
Review
2004
The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status. Whenever the cellular ATP:ADP ratio falls… (More)
  • figure 2
  • figure 1
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Inactivating mutations in the protein kinase LKB1 lead to a dominantly inherited cancer in humans termed Peutz-Jeghers syndrome… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2003
Highly Cited
2003
BACKGROUND The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?