FAQ

STAT3 wt Allele

Known as: APRF, Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) wt Allele 
Human STAT3 wild-type allele is located in the vicinity of 17q21 and is approximately 75 kb in length. This allele, which encodes signal transducer… (More)

Topic mentions per year

Topic mentions per year

1993-2001
0119932001

Related topics

Related topics

15 relations
17q21.31Adipocytokine Signaling PathwayCrohn DiseaseERBB2 Signaling Pathway
(More)

Broader (1)

STAT3 gene

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
STAT3 wt Allele
Signal Transduction
Crohn Disease
Homo sapiens
Transcriptional Regulation
Stat3 protein

Papers overview

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Highly Cited
2001
Highly Cited
2001
Platelet, but not endothelial, P-selectin is critical for neutrophil-mediated acute postischemic renal failure.
In a neutrophil-dependent model of acute postischemic renal failure (APRF), eliminating or blocking P-selectin reduces… (More)
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1999
1999
[Expression of interleukin-6 and its receptors in peripheral blood of patients with systemic lupus erythematosus].
OBJECTIVE To investigate the level of interleukin-6 (IL-6) and soluble-IL-6 receptor (sIL-6R) in serum of patients with systemic… (More)
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1996
1996
Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of…
Distinct yet overlapping sets of STAT transcription factors are activated by different cytokines. One example is the differential… (More)
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Highly Cited
1996
Highly Cited
1996
Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif…
Interleukin-6 (IL-6) and gamma-interferon (IFNgamma) activate an overlapping set of genes via the Jak/STAT pathway. However, at… (More)
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1996
1996
Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor.
Based on the reports of the activation of the transcription factor known as STAT3 (for signal transducers and activators of… (More)
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1995
1995
Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction.
The cytokine interleukin-6 (IL-6) rapidly activates a latent cytoplasmic transcription factor, acute-phase response factor (APRF… (More)
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Highly Cited
1994
Highly Cited
1994
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
Acute-phase response factor (APRF) is a transcription factor that binds to the interleukin-6 (IL-6)-responsive elements… (More)
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Highly Cited
1994
Highly Cited
1994
Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.
Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor… (More)
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1994
1994
Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential.
We have studied transcription factors that are coupled to the activation of cytokine receptors in liver and in mammary epithelial… (More)
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Highly Cited
1993
Highly Cited
1993
Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.
Interleukin-6 (IL-6) is known to be a major mediator of the acute-phase response in liver. We show here that IL-6 triggers the… (More)
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