STAT3 Inhibitor OPB-31121

Known as: OPB-31121 
An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. OPB-31121… (More)
National Institutes of Health

Papers overview

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2015
2015
PURPOSE OPB-31121 is an oral STAT3 inhibitor with a good preclinical antitumor activity. This phase I dose-escalation study of… (More)
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2015
2015
STAT3 is a key element in many oncogenic pathways and, like other transcription factors, is an attractive target for development… (More)
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2015
2015
AIM To evaluate the safety, pharmacokinetics and antitumor activity of OPB-31121, a signal transducer and activator of… (More)
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2014
2014
AbstractPurpose To determine the maximum tolerated dose (MTD) and biologic activity of OPB-31121, an oral inhibitor of STAT3… (More)
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2014
2014
2616 Background: OPB-31121 is an orally administered novel STAT3 inhibitor. STAT3 is found to be activated in the majority of HCC… (More)
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Highly Cited
2013
Highly Cited
2013
We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3 inhibitor, in gastric cancer cells… (More)
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2013
2013
Signal transduction and activator of transcription (STAT) proteins are extracellular ligand-responsive transcription factors that… (More)
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2011
2010
2010
e13056 Background: STAT pathway is activated in many solid tumors. OPB-31121 is an orally administered STAT3 inhibitor. We… (More)
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