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STAT3 Inhibitor OPB-31121

Known as: OPB-31121 
An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. OPB-31121… 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Purpose OPB-31121 is an oral STAT3 inhibitor with a good preclinical antitumor activity. This phase I dose-escalation study of… 
Highly Cited
2015
Highly Cited
2015
To evaluate the safety, pharmacokinetics and antitumor activity of OPB‐31121, a signal transducer and activator of transcription… 
Review
2015
Review
2015
Introduction: The clinical utility of effective direct STAT inhibitors, particularly STAT3 and STAT5, for treating cancer and… 
Highly Cited
2014
Highly Cited
2014
AbstractPurpose To determine the maximum tolerated dose (MTD) and biologic activity of OPB-31121, an oral inhibitor of STAT3… 
2014
2014
2616 Background: OPB-31121 is an orally administered novel STAT3 inhibitor. STAT3 is found to be activated in the majority of HCC… 
Highly Cited
2013
Highly Cited
2013
Signal transduction and activator of transcription (STAT) proteins are extracellular ligand-responsive transcription factors that… 
2011
2011
Abstract 577 Signal Transduction and Activator of Transcription (STAT) proteins are extracellular ligand-responsive transcription… 
2010
2010
e13056 Background: STAT pathway is activated in many solid tumors. OPB-31121 is an orally administered STAT3 inhibitor. We…