SS1(dsFv)PE38

Known as: SS1P, Immunotoxin, SS1(dsFv)-PE38, SS1(dsFv) PE38 
A recombinant immunotoxin consisting of the single chain anti-mesothelin monoclonal antibody SS1(dsFv) linked to Pseudomonas exotoxin PE-38. The… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Immunotoxins are potent anticancer agents with an unusual mechanism of action: inhibition of protein synthesis resulting in… (More)
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2013
2013
SS1P is a recombinant immunotoxin (RIT) engineered for the targeted elimination of malignant cells that express the tumor… (More)
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Review
2008
Review
2008
Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE To determine the toxicities, maximum tolerated dose (MTD) and pharmacokinetics of the recombinant immunotoxin SS1P (anti… (More)
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2007
2007
PURPOSE To determine the antitumor activity of the anti-mesothelin immunotoxin SS1P in combination with gemcitabine against… (More)
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2007
2007
Recombinant immunotoxins are chimeric proteins composed of the Fv portion of a tumor-specific antibody fused to a toxin. SS1P… (More)
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2006
2006
PURPOSE To investigate the combined antitumor activity in mice of immunotoxin SS1P and Taxol. METHODS Immunodeficient mice were… (More)
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2004
2004
BACKGROUND Mesothelin, a cell surface glycoprotein, is an attractive candidate for targeted therapy given its overexpression, as… (More)
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Review
2004
Review
2004
Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including… (More)
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2002
2002
PURPOSE Mesothelin, a cell surface glycoprotein overexpressed in ovarian cancer, mesotheliomas, and some squamous cell carcinomas… (More)
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