FAQ

SRSF2 gene

Known as: SRSF2, SPLICING FACTOR, ARGININE/SERINE-RICH, 30-KD, B, SFRS2A 
This gene plays a role in RNA splicing.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2017
05101519922017

Related topics

Related topics

10 relations
Homo sapiensIntracellular TransportLigand BindingMolecular Transport
(More)

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
SRSF2 gene
Homo sapiens
RNA Binding
RNA Splicing
Intracellular Transport
Transcription Termination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.
Mutations affecting spliceosomal proteins are the most common mutations in patients with myelodysplastic syndromes (MDS), but… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.
Mutations in genes of the splicing machinery have been described recently in myelodysplastic syndromes (MDS). In the present… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Is this relevant?
2012
2012
SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival.
Among spliceosome component mutations, those involving SF3B1 are most frequent in myelodysplastic syndromes with ring… (More)
  • table 1
  • figure 1
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus
We have previously reported that mutations in the polymerase proteins PB1, PB2, PA, and the nucleocapsid protein NP resulting in… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis.
The members of the SR family of splicing regulators were initially characterized for their critical roles in constitutive and… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions.
Exonic splicing enhancers (ESEs) are important cis elements required for exon inclusion. Using an in vitro functional selection… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1997
1997
Quantitative digital analysis of diffuse and concentrated nuclear distributions of nascent transcripts, SC35 and poly(A).
Digital imaging microscopy was used to analyze the spatial distribution and levels of newly synthesized RNA in relation to steady… (More)
  • figure 2
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities.
ASF/SF2 and SC35 belong to a highly conserved family of nuclear proteins that are both essential for splicing of pre-mRNA in… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.
The SR proteins are a family of essential splicing factors highly conserved throughout metazoa. Here we examine the effects of… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.
The human pre-mRNA splicing factors SF2 and SC35 have similar electrophoretic mobilities, and both of them contain an N-terminal… (More)
Is this relevant?