SRR gene

Known as: ILV1, ISO1, SRR 
 
National Institutes of Health

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serine racemase

Papers overview

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2011
2011
Levels of <ce:small-caps>d</ce:small-caps>-serine in the brain and peripheral organs of serine racemase (<ce:italic>Srr</ce:italic>) knock-out mice
D-Serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, plays an important role in mammalian brain… (More)
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Highly Cited
2010
Highly Cited
2010
A Genome-Wide Association Study Identifies Susceptibility Variants for Type 2 Diabetes in Han Chinese
To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk… (More)
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2010
2010
Effect of Exposure to 1,800 MHz Electromagnetic Fields on Heat Shock Proteins and Glial Cells in the Brain of Developing Rats
The increasing use of mobile phones by children raise issues about the effects of electromagnetic fields (EMF) on the immature… (More)
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2007
2007
Induction of serine racemase expression and D-serine release from microglia by secreted amyloid precursor protein (sAPP).
Alzheimer's disease (AD) involves neuronal loss and reduction of synaptic density in specific brain region. Some of the neuronal… (More)
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2006
2006
Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase.
Mammalian serine racemase is a brain-enriched enzyme that converts L- into D-serine in the nervous system. D-Serine is an… (More)
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2006
2006
Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells.
In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was… (More)
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Highly Cited
2005
Highly Cited
2005
Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.
BACKGROUND We previously reported a reduction in serum levels of D-serine, an endogenous co-agonist of the N-methyl-D-aspartate… (More)
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Highly Cited
2003
Highly Cited
2003
D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors.
d-serine has been proposed as an endogenous modulator of N-methyl-d-aspartate (NMDA) receptors in many brain regions, but its… (More)
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2003
2003
Spatiotemporal relationships among D-serine, serine racemase, and D-amino acid oxidase during mouse postnatal development.
AIM To elucidate the spatiotemporal relationships among D-serine, serine racemase, and D-amino acid oxidase (EC 1.4.3.3; DAO) in… (More)
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Highly Cited
1999
Highly Cited
1999
Purification of serine racemase: biosynthesis of the neuromodulator D-serine.
High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D… (More)
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