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SRR gene

Known as: ILV1, ISO1, SRR 
National Institutes of Health

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1 relation
serine racemase

Papers overview

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Highly Cited
2009
Highly Cited
2009
Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior
A subset of glutamate receptors that are specifically sensitive to the glutamate analog N-methyl-D-aspartate (NMDA) are molecular… 
Highly Cited
2008
Highly Cited
2008
NMDA- and β-Amyloid1–42-Induced Neurotoxicity Is Attenuated in Serine Racemase Knock-Out Mice
d-Serine is detected in the brain and acts as a coagonist at the “glycine-site” of the NMDA-type glutamate receptor. Although d… 
Highly Cited
2008
Highly Cited
2008
Serine racemase is predominantly localized in neurons in mouse brain
D‐Serine is the endogenous ligand for the glycine binding site of the N‐methyl‐D‐aspartate (NMDA)‐type glutamate receptor (GluR… 
Highly Cited
2006
Highly Cited
2006
Neuron-derived D-Serine Release Provides a Novel Means to Activate N-Methyl-D-aspartate Receptors*
d-Serine is a coagonist of N-methyl-d-aspartate (NMDA) receptors that occurs at high levels in the brain. Biosynthesis of d… 
Highly Cited
2005
Highly Cited
2005
Identification of Multiple Serine Racemase (SRR) mRNA Isoforms and Genetic Analyses of SRR and DAO in Schizophrenia and d-Serine Levels
Highly Cited
2004
Highly Cited
2004
Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide
BackgroundRoles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli… 
Highly Cited
2003
Highly Cited
2003
d-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors
d-serine has been proposed as an endogenous modulator of N-methyl-d-aspartate (NMDA) receptors in many brain regions, but its… 
Highly Cited
2002
Highly Cited
2002
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-d-aspartate (NMDA) receptor coagonist d-serine
High levels of d-serine occur in the brain, challenging the notion that d-amino acids would not be present or play a role in… 
Highly Cited
2000
Highly Cited
2000
Human serine racemase: moleular cloning, genomic organization and functional analysis.
Highly Cited
1999
Highly Cited
1999
Purification of serine racemase: biosynthesis of the neuromodulator D-serine.
High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D… 
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