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SR 4554
Known as:
SR-4554
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Nitroimidazoles
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
2-Nitroimidazole as Potential Nanoprobe in Hypoxia Imaging by MRI/PET
A. Sharma
,
R. Sharma
2008
Corpus ID: 495784
2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19Fand 31P MR methods. Despite the success of…
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Review
2003
Review
2003
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
B. Seddon
,
G. Payne
,
+9 authors
P. Workman
Clinical Cancer Research
2003
Corpus ID: 18345313
PURPOSE To perform a Phase I study of SR-4554, a fluorinated 2-nitroimidazole noninvasive probe of tumor hypoxia detected by (19…
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Review
2003
Review
2003
The role of functional and molecular imaging in cancer drug discovery and development.
B. Seddon
,
P. Workman
British Journal of Radiology
2003
Corpus ID: 25681581
Studies of pharmacokinetics (which is what the body does to the drug) and pharmacodynamics (which is what the drug does to the…
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2002
2002
Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.
B. Seddon
,
R. Maxwell
,
+4 authors
P. Workman
Clinical Cancer Research
2002
Corpus ID: 28696
PURPOSE Tumor hypoxia is associated with poor prognosis and a more malignant tumor phenotype. SR-4554, a fluorinated 2…
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1998
1998
The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.
E. Aboagye
,
R. Maxwell
,
+4 authors
J. Griffiths
British Journal of Cancer
1998
Corpus ID: 1471022
The relationship between two methods of assessing tumour oxygenation in vivo, namely oxygen electrode measurement and magnetic…
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Highly Cited
1998
Highly Cited
1998
Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.
P. Mcsheehy
,
S. Robinson
,
+5 authors
J. Griffiths
Cancer Research
1998
Corpus ID: 15695657
The purpose of this study was to examine the effect of carbogen gas (95% O2-5% CO2) on uptake and metabolism of 5-fluorouracil…
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Highly Cited
1997
Highly Cited
1997
Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.
E. Aboagye
,
R. Maxwell
,
+6 authors
P. Workman
Cancer Research
1997
Corpus ID: 14141788
A novel probe, N-(2-hydroxy-3,3,3,-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554), has been used to detect tumor…
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1997
1997
Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554).
E. Aboagye
,
A. Lewis
,
M. Tracy
,
P. Workman
Biochemical Pharmacology
1997
Corpus ID: 37846576
1996
1996
The pharmacokinetics, bioavailability and biodistribution in mice of a rationally designed 2-nitroimidazole hypoxia probe SR-4554.
E. Aboagye
,
A. Lewis
,
+4 authors
P. Workman
Anti-Cancer Drug Design
1996
Corpus ID: 19965311
N-(2-Hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) is a fluorinated 2-nitroimidazole which has been…
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1995
1995
The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semiquantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy…
E. Aboagye
,
A. Lewis
,
A. Johnson
,
P. Workman
,
M. Tracy
,
I. Huxham
British Journal of Cancer
1995
Corpus ID: 4885491
The novel fluorinated 2-nitroimidazole SR-4554 is undergoing preclinical development as a magnetic resonance spectroscopy and…
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