SPHK2 gene

Known as: SPHINGOSINE KINASE 2, SPHK2, Sphingosine Kinase 2 Gene 
This gene is involved in the biosynthesis of sphingosine 1- phosphate.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
The potent lipid mediator sphingosine-1-phosphate (S1P) regulates diverse physiological processes by binding to 5 specific GPCRs… (More)
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Highly Cited
2007
Highly Cited
2007
Sphingosine kinase (SPHK) is a key enzyme producing important messenger sphingosine 1-phosphate and is implicated in cell… (More)
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2007
2007
Sphingosine-1-phosphate (S1P) is a lipid mediator that exerts multiple cellular functions through activation of a subfamily of G… (More)
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2007
2007
The clinical immunosuppressant FTY720 is a sphingosine analogue that, once phosphorylated by sphingosine kinase 2 (Sphk2), is an… (More)
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Highly Cited
2005
Highly Cited
2005
The potent sphingolipid metabolite sphingosine 1-phosphate is produced by phosphorylation of sphingosine catalyzed by sphingosine… (More)
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Highly Cited
2005
Highly Cited
2005
Sphingosine-1-phosphate is a bioactive lipid that is mitogenic for human glioma cell lines by signaling through its G protein… (More)
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Highly Cited
2003
Highly Cited
2003
The potent immunosuppressive drug FTY720, a sphingosine analog, induces redistribution of lymphocytes from circulation to… (More)
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Highly Cited
2003
Highly Cited
2003
There are two isoforms of sphingosine kinase (SphK) that catalyze the formation of sphingosine 1-phosphate, a potent sphingolipid… (More)
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2003
2003
Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid mediator, sphingosine 1-phosphate (S1P). S1P… (More)
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Highly Cited
2000
Highly Cited
2000
Sphingosine-1-phosphate (SPP) has diverse biological functions acting inside cells as a second messenger to regulate… (More)
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