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SOX10 Transcription Factor

Known as: SOX 10 Transcription Factor, Transcription Factor, SOX10, SOX-10 Transcription Factor 
Transcription factor SOX-10 (466 aa, ~50 kDa) is encoded by the human SOX10 gene. This protein is involved in the regulation of gene expression.
National Institutes of Health

Related topics

Related topics

11 relations
Cell NucleusDNA-Binding ProteinsGenes, RegulatorMorphogenesis
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Broader (1)

SOXE Transcription Factors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
A novel group of spindle cell tumors defined by S100 and CD34 co‐expression shows recurrent fusions involving RAF1, BRAF, and NTRK1/2 genes
Tumors characterized by co‐expression of S100 and CD34, in the absence of SOX10, remain difficult to classify. Triggered by a few… Expand
Highly Cited
2008
Highly Cited
2008
Sox10: A Pan-Schwannian and Melanocytic Marker
S100 protein is a sensitive marker for melanomas and peripheral nerve sheath tumors. It is, however, expressed by other… Expand
Highly Cited
2003
Highly Cited
2003
SOX10 Maintains Multipotency and Inhibits Neuronal Differentiation of Neural Crest Stem Cells
The mechanisms that establish and maintain the multipotency of stem cells are poorly understood. In neural crest stem cells… Expand
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Highly Cited
2002
Highly Cited
2002
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.
Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the… Expand
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Highly Cited
2001
Highly Cited
2001
The transcription factor Sox10 is a key regulator of peripheral glial development.
The molecular mechanisms that determine glial cell fate in the vertebrate nervous system have not been elucidated. Peripheral… Expand
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Highly Cited
2000
Highly Cited
2000
Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3
Abstract. Waardenburg syndrome (WS) is associated with neural crest-derived melanocyte deficiency caused by mutations in either… Expand
Highly Cited
2000
Highly Cited
2000
Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome.
Waardenburg syndrome (WS) is an autosomal dominant disorder with an incidence of 1 in 40 000 that manifests with sensorineural… Expand
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Highly Cited
1998
Highly Cited
1998
Sox10, a Novel Transcriptional Modulator in Glial Cells
Sox proteins are characterized by possession of a DNA-binding domain with similarity to the high-mobility group domain of the sex… Expand
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Highly Cited
1998
Highly Cited
1998
SOX10 mutation disrupts neural crest development in Dom Hirschsprung mouse model
Hirschsprung disease (HSCR, MIM ♯142623) is a multigenic neuocristopathy (neural crest disorder) characterized by absence of… Expand
Highly Cited
1998
Highly Cited
1998
SOX10 mutations in patients with Waardenburg-Hirschsprung disease
Waardenburg syndrome (WS; deafness with pigmentary abnormalities) and Hirschsprung's disease (HSCR; aganglionic megacolon) are… Expand
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