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SN 28049

Known as: SN-28049, SN28049 
National Institutes of Health

Papers overview

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2014
2014
Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent
AbstractPurpose SN 28049 is a new DNA-binding topoisomerase II poison identified by its curative activity against the murine… 
2013
2013
Tumour tissue selectivity in the uptake and retention of SN 28049, a new topoisomerase II-directed anticancer agent
AbstractPurpose A variety of anticancer drugs, including doxorubicin and mitoxantrone, have structures in which a DNA… 
2013
2013
Factors influencing tumour uptake and retention of benzonaphthyridine derivatives in mice
The DNA-binding benzonaphthyridine derivatives have demonstrated to have high and even curative activity against the Colon-38… 
2012
2012
Comparison of a homologous series of benzonaphthyridine anti-cancer agents in mice: divergence between tumour and plasma pharmacokinetics
PurposeN-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide (SN 28049), a DNA… 
2011
2011
In vivo and in vitro assessment of the action of SN 28049, a benzonaphthyridine derivative targeting topoisomerase II, on the murine Colon 38 carcinoma
SummaryAim: SN 28049 (N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide) is a new… 
2010
2010
Pharmacokinetics and distribution of SN 28049, a novel DNA binding anticancer agent, in mice
PurposeN-[2-(Dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide (SN 28049) is a potent… 
2010
2010
In vivo and in vitro assessment of the action of the antitumour benzonaphthyridine derivative SN 28049 on the murine Colon 38
2008
2008
The mechanism of anti-tumour activity of the DNA binding agent SN 28049
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2007
2007
Assessment of the action of a new DNA-targeting agent, SN 28049 in two novel murine cell lines
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