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SMPD2 gene
Known as:
SPHINGOMYELIN PHOSPHODIESTERASE 2, NEUTRAL MEMBRANE
, sphingomyelin phosphodiesterase 2
, SMPD2
Â
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This gene is involved in sphingomyelin catabolism.
National Institutes of Health
Topic mentions per year
Topic mentions per year
2000-2017
0
1
2
2000
2017
Related topics
Related topics
6 relations
Hydrolysis
Phospholipid Metabolism
Receptor Signaling
SMPD3 gene
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Narrower (1)
SMPD2 wt Allele
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
SMPD2 gene
Hydrolysis
Phospholipid Metabolism
Receptor Signaling
Sphingomyelin Phosphodiesterase 2
SMPD3 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Trivalent chromium induces autophagy by activating sphingomyelin phosphodiesterase 2 and increasing cellular ceramide levels in renal HK2 cells.
Cheng-Lin Yang
,
Shiow-Her Chiou
,
Wei-Chun Tai
,
Nithila A Joseph
,
Kuan-Chih Chow
Molecular carcinogenesis
2017
In this study, we examined the role of autophagy in the initiation of lipid increases in renal epithelial HK2 cells. We found…Â
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2013
2013
Identification of C18:1-phytoceramide as the candidate lipid mediator for hydroxyurea resistance in yeast.
Nabil Matmati
,
Alessandra Metelli
,
Kaushlendra Tripathi
,
Shuqi Yan
,
Bidyut K. Mohanty
,
Yusuf A. Hannun
The Journal of biological chemistry
2013
Recent studies showed that deletion of ISC1, the yeast homologue of the mammalian neutral sphingomyelinase, resulted in an…Â
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2011
2011
Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae.
Kaushlendra Tripathi
,
Nabil Matmati
,
W. Jim Zheng
,
Yusuf A. Hannun
,
Bidyut K. Mohanty
Genetics
2011
In Saccharomyces cerevisiae, replication stress induced by hydroxyurea (HU) and methyl methanesulfonate (MMS) activates DNA…Â
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2009
2009
ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae.
H. Kitagaki
,
L. Ashley Cowart
,
+7 authors
Yusuf A. Hannun
The Journal of biological chemistry
2009
Growth of Saccharomyces cerevisiae following glucose depletion (the diauxic shift) depends on a profound metabolic adaptation…Â
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2006
2006
Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae.
L. Ashley Cowart
,
Yasuo Okamoto
,
Xinghua Lu
,
Yusuf A. Hannun
The Biochemical journal
2006
Saccharomyces cerevisiae produces the sphingolipid ceramide by de novo synthesis as well as by hydrolysis of complex…Â
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2003
2003
Functional analysis of ISC1 by site-directed mutagenesis.
Yasuo Okamoto
,
Silvia Vaena de Avalos
,
Yusuf A. Hannun
Biochemistry
2003
We previously reported that the yeast Saccharomyces cerevisiae ISC1 gene (Yer019w), which has homology to the bacterial…Â
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2002
2002
Structural requirements for selective binding of ISC1 to anionic phospholipids.
Yasuo Okamoto
,
Silvia Vaena de Avalos
,
Yusuf A. Hannun
The Journal of biological chemistry
2002
Yeast ISC1 (Yer019w) encodes inositolphosphosphingolipid-phospholipase C and is activated by phosphatidylserine (PS) and…Â
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2002
2002
ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae.
Christian Betz
,
Dirk M. Zajonc
,
Matthias Moll
,
Eckhart Schweizer
European journal of biochemistry
2002
In Saccharomyces cerevisiae, toxic concentrations of Na+ orLi+ ions induce the expression of the cation-extrusion ATPase gene…Â
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2001
2001
Coordination between fission yeast glucan formation and growth requires a sphingolipase activity.
Anna Feoktistova
,
Paula E. Magnelli
,
+4 authors
K. Lance Gould
Genetics
2001
css1 mutants display a novel defect in Schizosaccharomyces pombe cell wall formation. The mutant cells are temperature-sensitive…Â
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2000
2000
Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae.
Hiromi Sawai
,
Y. Okamoto
,
+4 authors
Yasuf A Hannun
The Journal of biological chemistry
2000
Sphingolipids have emerged as novel bioactive mediators in eukaryotic cells including yeast. It has been proposed that…Â
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