SMPD2 gene

Thrombin activates platelets mainly through protease-activated receptor (PAR)1 and PAR4. However, downstream platelet signaling… Expand

Ceramide has been suggested to participate in the neuronal cell death that leads to Alzheimer's disease (AD), but its role is not… Expand

Sphingolipids such as ceramide are recognized as vital regulators of many biological processes. Neutral sphingomyelinase 2… Expand

Growth of Saccharomyces cerevisiae following glucose depletion (the diauxic shift) depends on a profound metabolic adaptation… Expand

In recent years, sphingolipids have emerged as critical molecules in the regulation of microbial pathogenesis. In fungi, the… Expand

Saccharomyces cerevisiae produces the sphingolipid ceramide by de novo synthesis as well as by hydrolysis of complex… Expand

Sphingomyelinases (SMases) generate ceramides, which are known to regulate cell cycle and growth. Only one enzyme that belongs to… Expand

Human immunodeficiency virus type 1 (HIV-1) infection is known to cause disorders of the CNS, including HIV-associated dementia… Expand

Sphingolipids have emerged as novel bioactive mediators in eukaryotic cells including yeast. It has been proposed that… Expand

The enzymatic breakdown of sphingomyelin by sphingomyelinases is considered the major source of the second messenger ceramide… Expand