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SMPD2 gene

Known as: SPHINGOMYELIN PHOSPHODIESTERASE 2, NEUTRAL MEMBRANE, sphingomyelin phosphodiesterase 2, SMPD2 
This gene is involved in sphingomyelin catabolism.
National Institutes of Health

Related topics

Related topics

6 relations
HydrolysisPhospholipid MetabolismReceptor SignalingSMPD3 gene

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SMPD2 wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling
Neutral sphingomyelinase (nSMase) activation in response to environmental stress or inflammatory cytokine stimuli generates the… 
Highly Cited
2013
Highly Cited
2013
Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets
Thrombin activates platelets mainly through protease-activated receptor (PAR)1 and PAR4. However, downstream platelet signaling… 
2011
2011
Identification of Novel Anionic Phospholipid Binding Domains in Neutral Sphingomyelinase 2 with Selective Binding Preference*
Sphingolipids such as ceramide are recognized as vital regulators of many biological processes. Neutral sphingomyelinase 2… 
Review
2010
Review
2010
Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses
Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular… 
Highly Cited
2006
Highly Cited
2006
The Cryptococcal Enzyme Inositol Phosphosphingolipid-Phospholipase C Confers Resistance to the Antifungal Effects of Macrophages and Promotes Fungal Dissemination to the Central Nervous System
ABSTRACT In recent years, sphingolipids have emerged as critical molecules in the regulation of microbial pathogenesis. In fungi… 
2006
2006
Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae.
Saccharomyces cerevisiae produces the sphingolipid ceramide by de novo synthesis as well as by hydrolysis of complex… 
Highly Cited
2004
Highly Cited
2004
Activation and Localization of Inositol Phosphosphingolipid Phospholipase C, Isc1p, to the Mitochondria during Growth of Saccharomyces cerevisiae*
Sphingomyelinases (SMases) generate ceramides, which are known to regulate cell cycle and growth. Only one enzyme that belongs to… 
Highly Cited
2004
Highly Cited
2004
Human Immunodeficiency Virus Type 1 gp120 Induces Apoptosis in Human Primary Neurons through Redox-Regulated Activation of Neutral Sphingomyelinase
Human immunodeficiency virus type 1 (HIV-1) infection is known to cause disorders of the CNS, including HIV-associated dementia… 
Highly Cited
2000
Highly Cited
2000
Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase.
The enzymatic breakdown of sphingomyelin by sphingomyelinases is considered the major source of the second messenger ceramide… 
Highly Cited
2000
Highly Cited
2000
Identification of ISC1 (YER019w) as Inositol Phosphosphingolipid Phospholipase C inSaccharomyces cerevisiae *
Sphingolipids have emerged as novel bioactive mediators in eukaryotic cells including yeast. It has been proposed that… 
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