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SMPD2 gene

Known as: SPHINGOMYELIN PHOSPHODIESTERASE 2, NEUTRAL MEMBRANE, sphingomyelin phosphodiesterase 2, SMPD2 
This gene is involved in sphingomyelin catabolism.
National Institutes of Health

Papers overview

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2013
2013
Thrombin activates platelets mainly through protease-activated receptor (PAR)1 and PAR4. However, downstream platelet signaling… Expand
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Highly Cited
2012
Highly Cited
2012
Ceramide has been suggested to participate in the neuronal cell death that leads to Alzheimer's disease (AD), but its role is not… Expand
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2011
2011
Sphingolipids such as ceramide are recognized as vital regulators of many biological processes. Neutral sphingomyelinase 2… Expand
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2009
2009
Growth of Saccharomyces cerevisiae following glucose depletion (the diauxic shift) depends on a profound metabolic adaptation… Expand
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Highly Cited
2006
Highly Cited
2006
In recent years, sphingolipids have emerged as critical molecules in the regulation of microbial pathogenesis. In fungi, the… Expand
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2006
2006
Saccharomyces cerevisiae produces the sphingolipid ceramide by de novo synthesis as well as by hydrolysis of complex… Expand
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2004
2004
Sphingomyelinases (SMases) generate ceramides, which are known to regulate cell cycle and growth. Only one enzyme that belongs to… Expand
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Highly Cited
2004
Highly Cited
2004
Human immunodeficiency virus type 1 (HIV-1) infection is known to cause disorders of the CNS, including HIV-associated dementia… Expand
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Highly Cited
2000
Highly Cited
2000
Sphingolipids have emerged as novel bioactive mediators in eukaryotic cells including yeast. It has been proposed that… Expand
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Highly Cited
2000
Highly Cited
2000
The enzymatic breakdown of sphingomyelin by sphingomyelinases is considered the major source of the second messenger ceramide… Expand
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