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SMAD5 protein, human

Known as: Mothers Against Decapentaplegic Homolog 5, MAD Homolog 5, SMA- and MAD-Related Protein 5 
Mothers against decapentaplegic homolog 5 (465 aa, ~52 kDa) is encoded by the human SMAD5 gene. This protein is involved in transcriptional… 
National Institutes of Health

Related topics

Related topics

13 relations
BMP Receptor Signaling PathwayDNA-Binding ProteinsGenes, RegulatorPattern Formation
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Smad5 Protein

Papers overview

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2017
2017
MicroRNA-33 protects against neointimal hyperplasia induced by arterial mechanical stretch in the grafted vein
Aims Mechanical factors play significant roles in neointimal hyperplasia after vein grafting, but the mechanisms are not fully… 
Highly Cited
2014
Highly Cited
2014
Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling
Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I… 
Highly Cited
2011
Highly Cited
2011
Kaposi's Sarcoma-Associated Herpesvirus-Encoded MicroRNA miR-K12-11 Attenuates Transforming Growth Factor Beta Signaling through Suppression of SMAD5
ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 12 pre-microRNAs (pre-miRNAs). Current studies have shown that… 
2011
2011
Dynamic analysis of BMP‐responsive smad activity in live zebrafish embryos
Bone morphogenetic proteins (BMPs) are critical players in development and disease, regulating such diverse processes as… 
Highly Cited
2007
Highly Cited
2007
Smad1 and Smad5 differentially regulate embryonic hematopoiesis.
The bone morphogenetic protein (BMP) signaling pathway regulates multiple steps of hematopoiesis, mediated through receptor… 
2003
2003
Generation of a floxed allele of Smad5 for cre‐mediated conditional knockout in the mouse
Summary: Smad5 is a member of the Smad family of intracellular mediators of BMP signals and in endothelial cells of TGF‐β signals… 
Highly Cited
2001
Highly Cited
2001
The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo.
Ventral specification of mesoderm and ectoderm depends on signaling by members of the bone morphogenetic protein (Bmp) family… 
Highly Cited
1999
Highly Cited
1999
Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo
smad1 and smad5 encode transcription factors that have been implicated in the transduction of signaling by the bone morphogenetic… 
1998
1998
hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors
hSmad (mothers against decapentaplegic)-related proteins are important messengers within the Transforming Growth Factor-β1 (TGF… 
Highly Cited
1997
Highly Cited
1997
Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts.
Bone morphogenetic protein-2 (BMP-2) inhibits terminal differentiation of C2C12 myoblasts and converts them into osteoblast… 
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