FAQ

SMAD5 protein, human

Known as: Mothers Against Decapentaplegic Homolog 5, MAD Homolog 5, SMA- and MAD-Related Protein 5 
Mothers against decapentaplegic homolog 5 (465 aa, ~52 kDa) is encoded by the human SMAD5 gene. This protein is involved in transcriptional… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
012319972017

Related topics

Related topics

13 relations
BMP Receptor Signaling PathwayDNA-Binding ProteinsGenes, RegulatorPattern Formation
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Broader (1)

Smad5 Protein

Related mentions per year

Related mentions per year

1945-2018
19401960198020002020
SMAD5 protein, human
Signal Transduction
Transcriptional Activation
Transcriptional Regulation
dna binding
Receptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection.
Chronic human immunodeficiency virus and simian immunodeficiency virus (HIV and SIV) infections are characterized by mucosal… (More)
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2014
2014
Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5.
Bone morphogenetic proteins (BMPs) are multifunctional growth factors that play crucial roles during embryonic development and… (More)
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2012
2012
Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5.
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 12 pre-microRNAs (pre-miRNAs). Current studies have shown that these… (More)
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2011
2011
Dynamic analysis of BMP-responsive smad activity in live zebrafish embryos.
Bone morphogenetic proteins (BMPs) are critical players in development and disease, regulating such diverse processes as… (More)
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Highly Cited
2004
Highly Cited
2004
Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells.
Bone morphogenetic protein-7 (BMP7) is expressed in adult kidney and reduces renal fibrogenesis when given exogenously to rodents… (More)
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Review
2004
Review
2004
Smad5: signaling roles in hematopoiesis and osteogenesis.
Smad5 belongs to the receptor-activated Smad that function as intracellular signal transducers for transforming growth factor… (More)
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Highly Cited
2001
Highly Cited
2001
Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy.
Bone morphogenetic protein-7 (BMP7), a member of the transforming growth factor-beta (TGF-beta) superfamily of cytokines, is… (More)
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1999
1999
Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo.
Smad1 and smad5 encode transcription factors that have been implicated in the transduction of signaling by the bone morphogenetic… (More)
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1998
1998
hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors
hSmad (mothers against decapentaplegic)-related proteins are important messengers within the Transforming Growth Factor-β1 (TGF… (More)
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Highly Cited
1997
Highly Cited
1997
Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts.
Bone morphogenetic protein-2 (BMP-2) inhibits terminal differentiation of C2C12 myoblasts and converts them into osteoblast… (More)
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