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SMAD5 protein, human

Known as: Mothers Against Decapentaplegic Homolog 5, MAD Homolog 5, SMA- and MAD-Related Protein 5 
Mothers against decapentaplegic homolog 5 (465 aa, ~52 kDa) is encoded by the human SMAD5 gene. This protein is involved in transcriptional… Expand
National Institutes of Health

Related topics

Related topics

13 relations
BMP Receptor Signaling PathwayDNA-Binding ProteinsGenes, RegulatorPattern Formation
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Broader (1)

Smad5 Protein

Papers overview

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2014
2014
Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling
Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I… Expand
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2014
2014
Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5.
Bone morphogenetic proteins (BMPs) are multifunctional growth factors that play crucial roles during embryonic development and… Expand
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Highly Cited
2012
Highly Cited
2012
Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5.
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes 12 pre-microRNAs (pre-miRNAs). Current studies have shown that these… Expand
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2011
2011
Dynamic analysis of BMP-responsive smad activity in live zebrafish embryos.
Bone morphogenetic proteins (BMPs) are critical players in development and disease, regulating such diverse processes as… Expand
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2007
2007
Smad1 and Smad5 differentially regulate embryonic hematopoiesis.
The bone morphogenetic protein (BMP) signaling pathway regulates multiple steps of hematopoiesis, mediated through receptor… Expand
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2003
2003
Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.
Smad5 is a member of the Smad family of intracellular mediators of BMP signals and in endothelial cells of TGF-beta signals. We… Expand
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Highly Cited
2001
Highly Cited
2001
The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryo.
Ventral specification of mesoderm and ectoderm depends on signaling by members of the bone morphogenetic protein (Bmp) family… Expand
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1999
1999
Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo.
Smad1 and smad5 encode transcription factors that have been implicated in the transduction of signaling by the bone morphogenetic… Expand
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1999
1999
A maternal RNA encoding smad1/5 is segregated to animal blastomeres during ascidian development.
Expressed Sequence Tag (EST) research on the ascidian Halocynthia roretzi revealed that Hrsmad1/5, a homolog of smad genes, is… Expand
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Highly Cited
1997
Highly Cited
1997
Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts.
Bone morphogenetic protein-2 (BMP-2) inhibits terminal differentiation of C2C12 myoblasts and converts them into osteoblast… Expand
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