SLC7A11 wt Allele

Known as: SLC7A11, XCT, Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 11 wt Allele 
Human SLC7A11 wild-type allele is located within 4q28-q32 and is approximately 78 kb in length. This allele, which encodes cystine/glutamate… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Although p53-mediated cell-cycle arrest, senescence and apoptosis serve as critical barriers to cancer development, emerging… (More)
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Review
2015
Review
2015
Tumor cells have an increased demand for amino acids because of their rapid proliferation rate. In addition to their need in… (More)
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Highly Cited
2011
Highly Cited
2011
The regulation of gene expression in response to environmental signals and metabolic imbalances is a key step in maintaining… (More)
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Highly Cited
2011
Highly Cited
2011
To pursue a systematic approach to discovery of mechanisms of action of traditional Chinese medicine (TCM), we used microarrays… (More)
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Highly Cited
2011
Highly Cited
2011
MicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor… (More)
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Highly Cited
2008
Highly Cited
2008
The glutathione-dependent system is one of the key systems regulating cellular redox balance, and thus cell fate. Cysteine… (More)
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Highly Cited
2006
Highly Cited
2006
The cystine/glutamate exchanger (xCT) provides intracellular cyst(e)ine for production of glutathione, a major cellular… (More)
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Highly Cited
2005
Highly Cited
2005
SLC7A11 (xCT), together with SLC3A2 (4F2hc), encodes the heterodimeric amino acid transport system x(c)-, which mediates cystine… (More)
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Highly Cited
2005
Highly Cited
2005
In mammals, >100 genes regulate pigmentation by means of a wide variety of developmental, cellular, and enzymatic mechanisms… (More)
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Highly Cited
2002
Highly Cited
2002
In mammalian cultured cells, the cystine/glutamate exchange transport mediated by system x(c)- is important to maintain… (More)
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