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OBJECTIVE To identify a gene-based signature as a novel prognostic model in lower grade gliomas. RESULTS A gene signature… Expand Aims/hypothesisThe therapeutic benefit of physical activity to prevent and treat type 2 diabetes is commonly accepted. However… Expand TGF-ß is protective in atherosclerosis but deleterious in metastatic cancers. Our aim was to determine whether TGF… Expand Denervation by sciatic nerve resection causes decreased muscle glucose transporter 4 (GLUT4) expression, but little is known… Expand The insulin-responsive glucose transporter, GLUT4, is regulated in various physiologic states at the transcriptional level. When… Expand 1 Skeletal muscle is a highly plastic tissue that has a remarkable ability to adapt to external demands, such as exercise. Many… Expand Overexpression of GLUT4 exclusively in skeletal muscle enhances insulin action and improves glucose homeostasis. Transgenic… Expand Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in exon 1 of the HD gene, and the… Expand Glucose transport into muscle is important for the maintenance of normoglycemia. Thus, understanding mechanisms that regulate… Expand The GLUT4 gene is subject to complex tissue-specific and metabolic regulation, with a profound impact on insulin-mediated glucose… Expand