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SLC22A1 wt Allele

Known as: HOCT1, Solute Carrier Family 22 (Organic Cation Transporter), Member 1 wt Allele, OCT1 
Human SLC22A1 wild-type allele is located in the vicinity of 6q25.3 and is approximately 37 kb in length. This allele, which encodes solute carrier… 
National Institutes of Health

Related topics

Related topics

11 relations
6q25.3Biogenic Amine Metabolic ProcessHomo sapiensIonophore activity

Broader (1)

SLC22A1 gene

Papers overview

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Highly Cited
2008
Highly Cited
2008
Expression of the Uptake Drug Transporter hOCT1 is an Important Clinical Determinant of the Response to Imatinib in Chronic Myeloid Leukemia
Some chronic myeloid leukemia (CML) patients do not respond to imatinib, whereas others lose an initial response. To identify… 
Highly Cited
2008
Highly Cited
2008
Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia.
We have previously shown that imatinib uptake into chronic myeloid leukemia (CML) cells is dependent on human organic cation… 
Highly Cited
2007
Highly Cited
2007
Metformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine
Metformin is a widely used oral antihyperglycemic drug for the treatment of type II diabetes mellitus. The intestinal absorption… 
Highly Cited
2003
Highly Cited
2003
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
Organic cation transporters play a critical role in the elimination of therapeutic compounds in the liver and the kidney. We used… 
Highly Cited
2002
Highly Cited
2002
Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3
Organic cation transporters (OCTs) are involved in the elimination of monoamines and cationic xenobiotics. To examine whether… 
Highly Cited
2002
Highly Cited
2002
Interactions of Human Organic Anion Transporters and Human Organic Cation Transporters with Nonsteroidal Anti-Inflammatory Drugs
The purpose of this study was to elucidate the interactions of human organic anion transporters (hOATs) and human organic cation… 
Review
1999
Review
1999
Molecular Pharmacology of Organic Cation Transporters in Kidney
The homeostasis of endogenous organic cations, such as choline and N P-methylnicotinamide, monoamine neurotransmitters, cationic… 
Highly Cited
1998
Highly Cited
1998
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Recently, a polyspecific organic cation transporter, hOCT1, was cloned from human liver. To date, limited studies examining the… 
Highly Cited
1997
Highly Cited
1997
Cloning and characterization of two human polyspecific organic cation transporters.
Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and… 
Highly Cited
1997
Highly Cited
1997
Cloning and functional expression of a human liver organic cation transporter.
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and… 
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