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SKA-31

 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
American Clinical Neurophysiology Society's standardized critical care EEG terminology: Interrater reliability and 2012 version
WCN 2013 No: 856 Topic: 1 — Epilepsy Clinical presentation and neurophysiological findings in patients with pineal region… Expand
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2013
2013
SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts.
AIMS Endothelial SK(Ca) and IK(Ca) channels play an important role in the regulation of vascular function and systemic blood… Expand
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2013
2013
SK channel-selective opening by SKA-31 induces hyperpolarization and decreases contractility in human urinary bladder smooth muscle.
Overactive bladder (OAB) is often associated with increased involuntary detrusor smooth muscle (DSM) contractions during the… Expand
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2013
2013
Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice.
BACKGROUND AND PURPOSE The calcium-activated potassium channel KCa3.1 is expressed in the vascular endothelium where its… Expand
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2013
2013
Functional expression of SK channels in murine detrusor PDGFR+ cells.
We sought to characterize molecular expression and ionic conductances in a novel population of interstitial cells (PDGFR… Expand
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2012
2012
Tuning electrical conduction along endothelial tubes of resistance arteries through Ca(2+)-activated K(+) channels.
RATIONALE Electrical conduction through gap junction channels between endothelial cells of resistance vessels is integral to… Expand
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2012
2012
Pharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility.
Small conductance Ca²⁺-activated K⁺ (SK) and intermediate conductance Ca(2+)-activated K⁺ (IK) channels are thought to be… Expand
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Highly Cited
2011
Highly Cited
2011
Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3
The relationship between cerebellar dysfunction, motor symptoms, and neuronal loss in the inherited ataxias, including the… Expand
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2011
2011
Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels.
AIM Endothelial membrane hyperpolarization mediated by KCa3.1 and KCa2.3 channels has been demonstrated to initiate endothelium… Expand
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Highly Cited
2009
Highly Cited
2009
Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.
Small-conductance (KCa2.1-2.3) and intermediate-conductance (KCa3.1) calcium-activated K(+) channels are critically involved in… Expand
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