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SKA-31

 
National Institutes of Health

Papers overview

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2015
2015
Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels
Abstract: Endothelial KCa2.3 and KCa3.1 channels contribute to the regulation of myogenic tone in resistance arteries by Ca2… Expand
Highly Cited
2013
Highly Cited
2013
American Clinical Neurophysiology Society's standardized critical care EEG terminology: Interrater reliability and 2012 version
WCN 2013 No: 856 Topic: 1 — Epilepsy Clinical presentation and neurophysiological findings in patients with pineal region… Expand
2013
2013
Functional expression of SK channels in murine detrusor PDGFRα+ cells
•  SK currents have been recorded from detrusor smooth muscle cells, but current density at physiological holding potentials is… Expand
2013
2013
Endothelium‐dependent hyperpolarization‐related relaxations diminish with age in murine saphenous arteries of both sexes
We investigated the effects of aging on the contributions of NO and endothelium‐dependent hyperpolarization (EDH) to endothelium… Expand
2013
2013
Activation of KCa3.1 by SKA‐31 induces arteriolar dilatation and lowers blood pressure in normo‐ and hypertensive connexin40‐deficient mice
The calcium‐activated potassium channel KCa3.1 is expressed in the vascular endothelium where its activation causes endothelial… Expand
2013
2013
SK channel-selective opening by SKA-31 induces hyperpolarization and decreases contractility in human urinary bladder smooth muscle.
Overactive bladder (OAB) is often associated with increased involuntary detrusor smooth muscle (DSM) contractions during the… Expand
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2013
2013
SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts.
AIMS Endothelial SK(Ca) and IK(Ca) channels play an important role in the regulation of vascular function and systemic blood… Expand
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Highly Cited
2011
Highly Cited
2011
Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3
The relationship between cerebellar dysfunction, motor symptoms, and neuronal loss in the inherited ataxias, including the… Expand
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2011
2011
Improvement of endothelium‐dependent vasodilations by SKA‐31 and SKA‐20, activators of small‐ and intermediate‐conductance Ca2+‐activated K+‐channels
Aim:  Endothelial membrane hyperpolarization mediated by KCa3.1 and KCa2.3 channels has been demonstrated to initiate endothelium… Expand
Highly Cited
2009
Highly Cited
2009
Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure
Small-conductance (KCa2.1-2.3) and intermediate-conductance (KCa3.1) calcium-activated K+ channels are critically involved in… Expand
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