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SK&F 104078

Known as: SK&F-104078, SKF 104078 
National Institutes of Health

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2 relations

Broader (2)

Adrenergic alpha-AntagonistsBenzazepines

Papers overview

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1993
1993
Desensitization of inhibitory prejunctional α2-adrenoceptors and putative imidazoline receptors on rabbit heart sympathetic nerves
SummaryTo find out whether sympathetic nerves of the rabbit heart possess pharmacologically relevant prejunctional imidazoline… 
Highly Cited
1991
Highly Cited
1991
Functional distribution of alpha 1- and alpha 2-adrenergic receptors in the coronary microcirculation.
BACKGROUND The goal of this study was to determine the functional distribution of alpha 1- and alpha 2-adrenergic receptors in… 
1991
1991
Ability of SK&F 104078 and SK&F 104856 to identify alpha-2 adrenoceptor subtypes in NCB20 cells and guinea pig lung.
Alpha-2 adrenoceptors were characterized in three tissue culture cell lines and in membrane homogenates of guinea pig lung via… 
1991
1991
α2‐Adrenoceptor blocking profile of SK&F 104078: further evidence for receptor subtypes
1 The ability of the putative, selective post‐junctional α2‐adrenoceptor antagonist, SK&F 104078 to antagonize the effects of… 
Highly Cited
1991
Highly Cited
1991
Evidence for heterogeneity of prejunctional alpha-2-adrenoceptors.
The interactions between SK&F 104078 and several selective alpha 2-adrenoceptor agonists at pre- and postjunctional alpha 2… 
1991
1991
Additional evidence for functional subclassification of alpha-2 adrenoceptors based on a new selective antagonist, SK&F 104856.
SK&F 104856 (2-vinyl-7-chloro-3,4,5,6-tetrahydro-4-methyl-thieno[4,3,2ef][3] benzazepine) shows a similar selectivity profile to… 
1990
1990
Functional characterization of neuronal pre and postsynaptic α2‐adrenoceptor subtypes in guinea‐pig submucosal plexus
1 The α2‐adrenoceptors on cell bodies of submucosal neurones, on presynaptic cholinergic nerve terminals innervating submucosal… 
1988
1988
Pharmacologic characterization of SK&F 104078, a novel alpha-2 adrenoceptor antagonist which discriminates between pre- and postjunctional alpha-2 adrenoceptors.
SK&F 104078 has been reported to be a moderately potent antagonist at postjunctional alpha-2 adrenoceptors in canine saphenous… 
1987
1987
Pharmacologic differentiation between pre- and postjunctional α2-adrenoceptors by SK & F 104078
SummaryMost α2-adrenoceptor antagonists do not discriminate between pre- and postjunctional α2-adrenoceptors, and this has led to… 
1987
1987
Pharmacologic differentiation between pre- and postjunctional alpha 2-adrenoceptors by SK&F 104078.
Most alpha 2-adrenoceptor antagonists do not discriminate between pre- and postjunctional alpha 2-adrenoceptors, and this has led… 
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