SIM1 gene

Known as: Single-Minded Homolog 1 (Drosophila) Gene, SINGLE-MINDED, DROSOPHILA, HOMOLOG OF, 1, SIM1 
This gene plays a role in transcription and neurogenesis.
National Institutes of Health

Papers overview

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2013
2013
Single-minded 1 (SIM1) is a basic helix-loop-helix transcription factor involved in the development and function of the… (More)
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2013
2013
Sim1 haploinsufficiency in mice induces hyperphagic obesity and developmental abnormalities of the brain. In humans… (More)
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2012
2012
Single-minded 1 (Sim1) is a transcription factor necessary for development of the paraventricular nucleus of the hypothalamus… (More)
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Highly Cited
2010
Highly Cited
2010
Single-minded 1 (SIM1) mutations are one of the few known causes of nonsyndromic monogenic obesity in both humans and mice… (More)
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2006
2006
Single-minded 1 (SIM1) is one of only six genes implicated in human monogenic obesity. Haploinsufficiency of this hypothalamic… (More)
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2004
2004
Haploinsufficiency of the transcription factor gene Sim1 has been previously implicated in hyperphagic obesity in humans and mice… (More)
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Highly Cited
2001
Highly Cited
2001
The bHLH-PAS transcription factor SIM1 is required for the development of the paraventricular nucleus (PVN) of the hypothalamus… (More)
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Highly Cited
2000
Highly Cited
2000
Studies of mice and humans have revealed a number of genes that when mutated result in severe obesity. We have studied a unique… (More)
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Highly Cited
2000
Highly Cited
2000
One major function of the hypothalamus is to maintain homeostasis by modulating the secretion of pituitary hormones. The… (More)
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Highly Cited
1998
Highly Cited
1998
The bHLH-PAS transcription factor SIM1 is expressed during the development of the hypothalamic-pituitary axis in three… (More)
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