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SHC3 protein, human

Known as: N-Shc protein, human, ShcC protein, human, Neuronal SHC 
Expressed in the brain by human SHC3 Gene, the 474-aa 52-kD and 594-aa 64-kD isoforms of Neuronal SHC are similar to SHC; nearly 70% homology in the… 
National Institutes of Health

Related topics

Related topics

8 relations
Adaptor Proteins, Signal TransducingAdaptor Signaling Protein GeneSHC3 geneSHC3 wt Allele

Broader (1)

Src Homology 2 Domain-Containing, Transforming Protein 3

Papers overview

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2008
2008
Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system
Abstract  The adaptor protein Rai (ShcC/N‐Shc) is almost exclusively present in the nervous system, although little is documented… 
2006
2006
Disruption of ShcA signaling halts cell proliferation--characterization of ShcC residues that influence signaling pathways using yeast.
Highly Cited
2005
Highly Cited
2005
N-Methyl-D-Aspartic acid suppresses Akt activity through protein phosphatase in retinal ganglion cells.
PURPOSE To investigate the relationship between Akt activity and retinal ganglion cell (RGC) death induced by N-Methyl-D-Aspartic… 
2005
2005
Domain-specific function of ShcC docking protein in neuroblastoma cells
ShcC is a family member of the Shc docking proteins that possess two different phosphotyrosine-binding motifs and conduct signals… 
2005
2005
Shc3 affects human high-grade astrocytomas survival
A selective switch from expression of Shc1 gene to Shc3 occurs with maturation of neuronal precursors into postmitotic neurons… 
2005
2005
Shc Family Expression in Neuroblastoma: High Expression of shcC Is Associated with a Poor Prognosis in Advanced Neuroblastoma
The biological features and prognosis of neuroblastoma, a neural crest-derived pediatric tumor, are closely associated with… 
2003
2003
Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment
The Shc family of proteins participates in mitogenic and survival signalling through binding to receptor tyrosine kinases. We… 
2002
2002
Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules
The phosphotyrosine (pTyr) adapter Shc/ShcA is a major connector in various tyrosine kinase signalings following a variety of… 
2002
2002
Comparative expression profiles of Trk receptors and Shc‐related phosphotyrosine adapters during retinal development: Potential roles of N‐Shc/ShcC in brain‐derived neurotrophic factor signal…
Neurotrophins (NTs) have multiple roles in retinal development and survival, which are mediated through their specific receptors… 
1996
1996
Binding Specificity and Mutational Analysis of the Phosphotyrosine Binding Domain of the Brain-specific Adaptor Protein ShcC (*)
Shc proteins (hereafter referred to as ShcA) represent major substrates of tyrosine phosphorylation by a wide variety of growth… 
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