SGPP2 gene

Known as: SPP2, SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE 2, SGPP2 
This gene plays a role in sphingosine-1-phosphate catabolism.
National Institutes of Health

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DephosphorylationHydrolysisSGPP2 protein, human

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SGPP2 wt Allele

Papers overview

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2016
2016
Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans.
The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it have been implicated in inflammatory… (More)
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2015
2015
Tumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2
To investigate the function of microRNA-31 (miR-31) in the pathogenesis of gastric cancer (GC) and to explore the possible… (More)
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2015
2015
SPP2 Mutations Cause Autosomal Dominant Retinitis Pigmentosa
Retinitis pigmentosa (RP) shows progressive loss of photoreceptors involved with heterogeneous genetic background. Here, by exome… (More)
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2015
2015
The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis.
BACKGROUND High-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) contributed to several beneficial effects in… (More)
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2015
2015
Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD)
INTRODUCTION We previously reported that alveolar macrophages from patients with chronic obstructive pulmonary disease (COPD) are… (More)
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2013
2013
A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
Studies in cell culture and mouse models of cancer have indicated that the soluble sphingolipid metabolite sphingosine 1… (More)
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2013
2013
Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function
BackgroundVitamin D is associated with lung health in epidemiologic studies, but mechanisms mediating observed associations are… (More)
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2012
2012
Annexin A1 Interaction with the FPR2/ALX Receptor
Understanding how proresolving agonists selectively activate FPR2/ALX is a crucial step in the clarification of proresolution… (More)
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2010
2010
Downstream Gene Activation of the Receptor ALX by the Agonist Annexin A1
BACKGROUND Our understanding of pro-resolution factors in determining the outcome of inflammation has recently gained ground, yet… (More)
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2005
2005
Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis.
OBJECTIVE To identify the gene expression profile of mandibular condylar cartilage after experimentally induced osteoarthritis… (More)
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