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SGN 40

Known as: SGN-14, SGN40 cpd, Monoclonal Antibody SGN-14 
A humanized monoclonal antibody targeting the CD40 antigen with potential antineoplastic activity. CD-40, an integral membrane protein found on the… 
National Institutes of Health

Related topics

Related topics

3 relations
NCIt Antineoplastic Agent Terminologyantigen binding

Broader (1)

dacetuzumab

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Enhanced T-cell-independent Antitumor Effect of Cyclophosphamide Combined With Anti-CD40 mAb and CpG in Mice
We have earlier demonstrated T-cell-independent antitumor effects of a combination of anti-CD40 monoclonal antibody (mAb) and CpG… 
2009
2009
Dacetuzumab (SGN-40), Lenalidomide, and Weekly Dexamethasone in Relapsed or Refractory Multiple Myeloma: Multiple Responses Observed in a Phase 1b Study.
Abstract 2870 Poster Board II-846 Background: Dacetuzumab (SGN-40) is a humanized monoclonal antibody that targets CD40. In prior… 
Review
2008
Review
2008
Manipulating B cell homeostasis: a key component in the advancement of targeted strategies
Understanding the homeostatic mechanisms governing lymphocyte pools achieves critical importance as lymphocyte-targeted therapies… 
2005
2005
A Phase I Humanized Anti-CD40 Monoclonal Antibody (SGN-40) in Patients with Multiple Myeloma.
SGN-40, a humanized anti-CD40 monoclonal antibody, is being evaluated in a phase I dose escalation study for patients with… 
2005
2005
A Phase I Study of Humanized Anti-CD40 Immunotherapy with SGN-40 in Non-Hodgkin’s Lymphoma.
The vast majority of B-cell malignancies express CD40, a member of the TNF receptor family. This receptor, along with the cognate… 
2000
2000
Synthetic oligodeoxynucleotides inhibit IgE induction in human lymphocytes.
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs have the capacity to stimulate T-helper (Th)1-type… 
2000
2000
Differential expression of the B cell‐restricted molecule CD22 on neonatal B lymphocytes depending upon antigen stimulation
Newborns respond poorly to certain antigens and produce mainly IgM antibodies. By flow cytometry we analyzed on neonatal and… 
1996
1996
B cell‐B cell interaction through intercellular adhesion molecule‐1 and lymphocyte functional antigen‐1 regulates immunoglobulin E synthesis by B cells stimulated with interleukin‐4 and anti‐CD40…
IgE synthesis by purified human B cells is induced by two signals: a class switching factor, most commonly interleukin (IL)‐4… 
1994
1994
Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE.
Highly Cited
1993
Highly Cited
1993
Induction by anti‐CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X‐linked hyper IgM syndrome
We studied the ability of B lymphocytes from patients with X‐linked hyper IgM syndrome (HIGM1) to be activated via the CD40… 
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