SGN 40

Known as: SGN-14, SGN40 cpd, Monoclonal Antibody SGN-14 
A humanized monoclonal antibody targeting the CD40 antigen with potential antineoplastic activity. CD-40, an integral membrane protein found on the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2016
051019902016

Papers overview

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2010
2010
Despite advances in therapy, chronic lymphocytic leukemia remains an incurable disease and novel, effective therapies are needed… (More)
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2010
2010
This first-in-human, phase I study evaluated the safety, maximum-tolerated dose, pharmacokinetics, and antitumor activity of… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE To evaluate the safety, maximum-tolerated dose (MTD), pharmacokinetics, and antitumor activity of dacetuzumab in patients… (More)
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Highly Cited
2005
Highly Cited
2005
Infusion of either embryonic or mesenchymal stem cells prolongs the survival of organ transplants derived from stem cell donors… (More)
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Highly Cited
2005
Highly Cited
2005
SGN-40, a humanized immoglobulin G1 (IgG1) anti-CD40 monoclonal antibody, mediates cytotoxicity against human multiple myeloma… (More)
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2005
2005
SGN-40 is a humanized IgG1 antihuman CD40 that is currently in a phase I clinical trial for the treatment of multiple myeloma. As… (More)
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2004
2004
CD40 is expressed on B-cell malignancies, including human multiple myeloma (MM) and a variety of carcinomas. We examined the… (More)
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Highly Cited
2002
Highly Cited
2002
Peripheral immune tolerance is believed to be induced by the processing and presentation of self-tissues that die during… (More)
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Highly Cited
1992
Highly Cited
1992
In the present report, we have investigated the in vitro differentiation of surface(s) sIgD+ and sIgD- human B cells into Ig… (More)
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Highly Cited
1990
Highly Cited
1990
A novel pathway of IgE-B cell differentiation has been identified. Engagement of the B cell antigen CD40 by F(ab')2 fragments of… (More)
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