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SGI-1027

National Institutes of Health

Papers overview

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2018
2018
SGI-1027, a novel class of relatively stable, highly lipophilic quinoline-based small-molecule inhibitors of DNA… 
2016
2016
Müller glia (MG) is the most abundant glial type in the vertebrate retina. Among its many functions, it is capable of responding… 
2014
2014
Quinoline derivative SGI‐1027 (N‐(4‐(2‐amino‐6‐methylpyrimidin‐4‐ylamino)phenyl)‐4‐(quinolin‐4‐ylamino)benzamide) was first… 
2014
2014
Background: 4-Aminoquinoline SGI-1027 and analogs inhibit DNA methylation, which is deregulated in cancers. Results: These… 
2014
2014
After extensive research on radiochemotherapy, 5-year survival rates of children with high risk neuroblastoma still do not exceed… 
2013
2013
DNA methylation is an epigenetic modification that regulates gene expression by DNA methyltransferases (DNMTs). Inhibition of… 
2012
2012
DNA methyltransferases (DNMTs) are emerging targets for the treatment of cancer and other diseases. The quinolone-based compound… 
Highly Cited
2009
Highly Cited
2009
Reactivation of silenced tumor suppressor genes by 5-azacytidine (Vidaza) and its congener 5-aza-2'-deoxycytidine (decitabine…