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SF 1126

Known as: SF-1126, SF1126, pan-PI3K/mTOR Inhibitor SF1126 
A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174… 
National Institutes of Health

Related topics

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3 relations

Broader (2)

ChromonesOligopeptides
NCIt Antineoplastic Agent Terminology

Papers overview

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2016
2016
Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Our previous studies showed that the angiogenic… 
2015
2015
Combination of SF1126 and gefitinib induces apoptosis of triple-negative breast cancer cells through the PI3K/AKT–mTOR pathway
To investigate the apoptotic mechanism of triple-negative breast cancer (TNBC) cells induced by gefitinib and PI3K inhibitor… 
2014
2014
Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in 12 V-Ha-Ras transgenic mouse glioma model
BackgroundGrowth factor mediated activation of RAS-MAP-kinase and PI3-kinase-AKT pathways are critical for the pathogenesis of… 
2013
2013
An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo
PurposeMultiple reports point to an important role for the phosphoinositide-3 kinase (PI3K) and AKT signaling pathways in tumor… 
2013
2013
Wnt-ß-Catenin Pathway Regulates Vascular Mimicry in Triple Negative Breast Cancer
The Wnt-beta-catenin pathway (WP) regulates different aspects of cell fate, migration and polarity. Inappropriate deregulation of… 
2012
2012
SF1126, a Pan-PI3K Inhibitor has Potent Pre-Clinical Activity in Aggressive B-Cell Non-Hodgkin Lymphomas by Inducing Cell Cycle Arrest and Apoptosis
The PI3K pathway is activated in a variety of human tumors including B-cell Non Hodgkin Lymphoma (B-NHL). Targeting this pathway… 
2011
2011
SF1126, a Pan-PI3K Inhibitor Has Superior Preclinical Activity to CAL-101 a PI3K Delta-Specific Inhibitor in Aggressive B-Cell Non-Hodgkin's Lymphoma
Abstract 2720 The PI3K pathway is constitutively active in B-cell non-Hodgkin lymphomas (B-NHL). PI3K pathway targeted therapies… 
2010
2010
Phase I Study of Novel Prodrug Dual PI3K/mTOR Inhibitor SF1126 In B-Cell Malignancies.
Abstract 1783 Background: The PI3K/Akt/mTOR signaling pathway is an attractive target to inhibit for cancer therapy because it is… 
2007
2007
Preclinical studies of a pan PI3K inhibitor (SF1126) in renal cell carcinoma
2378 The phosphatidylinositol 3-kinase /PTEN/AKT pathway is an important pathway that regulates a wide spectrum of tumor-related… 
2006
2006
A Vascular Targeted Pan PI-3 Kinase Inhibitor, SF1126 with Activity Against Multiple Myeloma In Vivo.
Background: Considerable evidence suggests an important role for the PI-3 kinase and AKT signaling pathways in survival and… 
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