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SF 1126

Known as: SF-1126, SF1126, pan-PI3K/mTOR Inhibitor SF1126 
A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174… Expand
National Institutes of Health

Papers overview

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2016
2016
Deregulated PI3K/AKT/mTOR, Ras/Raf/MAPK, and c-Myc signaling pathways are of prognostic significance in hepatocellular carcinoma… Expand
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Review
2015
Review
2015
The healthy immune system protects against infection and malignant transformation without causing significant damage to host… Expand
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2014
2014
UNLABELLED Tumor growth, progression, and response to the hypoxic tumor microenvironment involve the action of hypoxia-inducible… Expand
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2014
2014
Background: HIF1α is degraded under normoxic conditions by VHL. Degradation under hypoxia is poorly understood. Results: HIF1α is… Expand
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2014
2014
AbstractPurpose SF1126 is a vascular-targeted pan-PI-3K inhibitor prodrug with antitumor and antiangiogenic activity and has… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND SF1126 is a peptidic pro-drug inhibitor of pan-PI3K/mTORC. A first-in-human study evaluated safety, dose limiting… Expand
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2010
2010
PurposeStudies of SF1126, an RGDS targeted, water-soluble prodrug of LY294002, are currently nearing completion in two adult… Expand
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2009
2009
PurposeThe purpose of the current study is to determine the in vitro cytotoxic effects of the novel pan-PI3-kinase inhibitor… Expand
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Highly Cited
2008
Highly Cited
2008
PTEN and the pan phosphoinositide 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1 benzopyran-4-one (LY294002) exert… Expand
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Review
2007
Review
2007
The development of novel therapies for multiple myeloma depends on a comprehensive understanding of the events leading to… Expand
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