SF 1126

Known as: SF-1126, SF1126, pan-PI3K/mTOR Inhibitor SF1126 
A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2016
024620062016

Papers overview

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2015
2015
To investigate the apoptotic mechanism of triple-negative breast cancer (TNBC) cells induced by gefitinib and PI3K inhibitor… (More)
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2014
2014
Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor containing an inducibly expressed HIF1α subunit and a… (More)
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2014
2014
UNLABELLED Tumor growth, progression, and response to the hypoxic tumor microenvironment involve the action of hypoxia-inducible… (More)
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2014
2014
Growth factor mediated activation of RAS-MAP-kinase and PI3-kinase-AKT pathways are critical for the pathogenesis of glioblastoma… (More)
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2012
2012
BACKGROUND SF1126 is a peptidic pro-drug inhibitor of pan-PI3K/mTORC. A first-in-human study evaluated safety, dose limiting… (More)
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2010
2010
Studies of SF1126, an RGDS targeted, water-soluble prodrug of LY294002, are currently nearing completion in two adult Phase I… (More)
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2010
2010
cover caption Nat. Chem. Biol. 6 (2010); published online 12 February 2010; corrected after print 18 March 2010 In the version of… (More)
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2009
2009
2558 Background: SF1126 is composed of the pan PI3K inhibitor LY294002 conjugated to an RGD targeting peptide. It is designed to… (More)
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2009
2009
The purpose of the current study is to determine the in vitro cytotoxic effects of the novel pan-PI3-kinase inhibitor SF1126 in… (More)
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Highly Cited
2008
Highly Cited
2008
PTEN and the pan phosphoinositide 3-kinase (PI3K) inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1 benzopyran-4-one (LY294002) exert… (More)
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