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SERPINE1 protein, human

Known as: SERPINE1, Serine or Cysteine Proteinase Inhibitor Clade E Member 1, Nexin 
Plasminogen activator inhibitor 1 (402 aa, ~45 kDa) is encoded by the human SERPINE1 gene. This protein plays a role in both cell adhesion and the… 
National Institutes of Health

Related topics

Related topics

9 relations
Genes, RegulatorPlasminogen Activator Inhibitor 2Plasminogen Activator Inhibitor-1 MeasurementRegulation of Proteolysis

Broader (2)

Plasminogen Activator Inhibitor 1Plasminogen Inactivators

Papers overview

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Highly Cited
2006
Highly Cited
2006
Evi1 is a survival factor which conveys resistance to both TGFβ- and taxol-mediated cell death via PI3K/AKT
In hematopoietic cells the transforming potential of the ecotropic viral integration site 1 (Evi1) oncogene is thought to be… 
Highly Cited
2003
Highly Cited
2003
Tumor Tissue Concentrations of the Proteinase Inhibitors Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and Plasminogen Activator Inhibitor Type 1 (PAI-1) Are Complementary in Determining…
The purpose of this study was to investigate the association between tumor tissue levels of total tissue inhibitor of… 
Highly Cited
1995
Highly Cited
1995
A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death.
Protease nexin I (PNI) is a member of the family of serine protease inhibitors (serpins) that have been shown to promote neurite… 
Highly Cited
1995
Highly Cited
1995
The insertion allele of the ACE gene I/D polymorphism. A candidate gene for insulin resistance?
BACKGROUND The insertion/deletion (ID) polymorphism of the angiotensin-converting enzyme (ACE) gene has been associated with… 
Highly Cited
1991
Highly Cited
1991
Functional interaction of plasminogen activator inhibitor type 1 (PAI-1) and heparin.
Plasminogen activator inhibitor type 1 (PAI-1), the fast-acting inhibitor of tissue-type plasminogen activator (t-PA) and… 
Highly Cited
1989
Highly Cited
1989
Blood Collection in Strong Acidic Citrate Anticoagulant Used in a Study of Dietary Influence on Basal tPA Activity
Summary Tissue plasminogen activator (tPA) activity in blood and blood plasma has been difficult to determine because it is… 
Highly Cited
1988
Highly Cited
1988
Tissue-type plasminogen activator binding to human endothelial cells. Evidence for two distinct binding sites.
Highly Cited
1986
Highly Cited
1986
Purification and characterization of a novel inhibitor of urokinase from human urine. Quantitation and preliminary characterization in plasma.
Highly Cited
1986
Highly Cited
1986
Inhibition of tumor-cell-mediated extracellular matrix destruction by a fibroblast proteinase inhibitor, protease nexin I.
Human fibrosarcoma (HT-1080) cells, in contrast to normal fibroblasts, rapidly hydrolyze the glycoprotein, collagen, and elastin… 
Highly Cited
1984
Highly Cited
1984
Purification of human fibroblast urokinase proenzyme and analysis of its regulation by proteases and protease nexin.
Recently we presented evidence that normal human foreskin fibroblasts (HF cells) limit the activity of secreted urokinase by… 
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