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SERPINE1 protein, human

Known as: SERPINE1, Serine or Cysteine Proteinase Inhibitor Clade E Member 1, Nexin 
Plasminogen activator inhibitor 1 (402 aa, ~45 kDa) is encoded by the human SERPINE1 gene. This protein plays a role in both cell adhesion and the… Expand
National Institutes of Health

Related topics

Related topics

9 relations
Genes, RegulatorPlasminogen Activator Inhibitor 2Plasminogen Activator Inhibitor-1 MeasurementRegulation of Proteolysis
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Broader (2)

Plasminogen Activator Inhibitor 1Plasminogen Inactivators

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport
The PDZ-domain-containing sorting nexin 27 (SNX27) promotes recycling of internalized transmembrane proteins from endosomes to… Expand
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Highly Cited
2011
Highly Cited
2011
SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signaling receptors
Endocytic sorting of signalling receptors between recycling and degradative pathways is a key cellular process controlling the… Expand
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Highly Cited
2009
Highly Cited
2009
Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure.
Increased mineralocorticoid levels plus high salt promote vascular inflammation and cardiac tissue remodeling. Mineralocorticoid… Expand
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Review
2005
Review
2005
Vitamin E, oxidative stress, and inflammation.
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the Western world. Its incidence has also been… Expand
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Highly Cited
2003
Highly Cited
2003
C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis.
BACKGROUND Inflammation plays a pivotal role in atherosclerosis. In addition to being a risk marker for cardiovascular disease… Expand
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Review
2003
Review
2003
Hemostasis during normal pregnancy and puerperium.
During normal pregnancy the hemostatic balance changes in the direction of hypercoagulability, thus decreasing bleeding… Expand
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Highly Cited
2001
Highly Cited
2001
Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.
Proteases are linked to the malignant phenotype of different solid tumors. Therefore, the expression of the matrix… Expand
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Highly Cited
2000
Highly Cited
2000
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
The hexosamine pathway has been implicated in the pathogenesis of diabetic complications. We determined first that hyperglycemia… Expand
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Highly Cited
1998
Highly Cited
1998
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.
Smad proteins play a key role in the intracellular signalling of transforming growth factor beta (TGF beta), which elicits a… Expand
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Highly Cited
1997
Highly Cited
1997
Production of Plasminogen Activator Inhibitor 1 by Human Adipose Tissue: Possible Link Between Visceral Fat Accumulation and Vascular Disease
Plasminogen activator inhibitor type 1 (PAI-1) contributes to the pathogenesis of atherothrombosis. Its plasma level is strongly… Expand
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